ePrints@IIScePrints@IISc Home | About | Browse | Latest Additions | Advanced Search | Contact | Help

Browse by Author

Up a level
Export as [feed] Atom [feed] RSS 1.0 [feed] RSS 2.0
Group by: Item Type | No Grouping
Number of items: 51.

Conference Paper

Kachroo, AH and Mahadevan, S and Varshney, U and Singh, S (2006) Mutations in the transcriptional regulator ChbR that allow cellobiose utilization in E.coli. In: Tenth Transcription Assembly, December 2006, Kolkatta.

Journal Article

Varshney, U (2023) Co-evolution of the translation apparatus and eukaryotes. In: Journal of Biosciences, 48 (4).

Kesharwani, S and Raj, P and Paul, A and Roy, K and Bhanot, A and Mehta, A and Gopal, A and Varshney, U and Gopal, B and Sundriyal, S (2023) Crystal structures of non-uracil ring fragments in complex with Mycobacterium tuberculosis uracil DNA glycosylase (MtUng) as a starting point for novel inhibitor design: A case study with the barbituric acid fragment. In: European Journal of Medicinal Chemistry, 258 .

Singh, S and Lahry, K and Mandava, CS and Singh, J and Shah, RA and Sanyal, S and Varshney, U (2023) Lamotrigine compromises the fidelity of initiator tRNA recruitment to the ribosomal P-site by IF2 and the RbfA release from 30S ribosomes in Escherichia coli. In: RNA Biology, 20 (1). pp. 681-692.

Sah, S and Varshney, U (2023) Methionyl-tRNA formyltransferase utilizes 10-formyldihydrofolate as an alternative substrate and impacts antifolate drug action. In: Microbiology (United Kingdom), 169 (2).

Naz, S and Paritosh, K and Sanyal, P and Khan, S and Singh, Y and Varshney, U and Nandicoori, VK (2023) GWAS and functional studies suggest a role for altered DNA repair in the evolution of drug resistance in Mycobacterium tuberculosis. In: eLife, 12 .

Raj, P and Selvam, K and Roy, K and Mani Tripathi, S and Kesharwani, S and Gopal, B and Varshney, U and Sundriyal, S (2022) Identification of a new and diverse set of Mycobacterium tuberculosis uracil-DNA glycosylase (MtUng) inhibitors using structure-based virtual screening: Experimental validation and molecular dynamics studies. In: Bioorganic and Medicinal Chemistry Letters, 76 .

Kapoor, I and Shaw, A and Naha, A and Emam, E A F and Varshney, U (2022) Role of the nucleotide excision repair pathway proteins (UvrB and UvrD2) in recycling UdgB, a base excision repair enzyme in Mycobacterium smegmatis. In: DNA Repair, 113 .

Raja, S and Paul, A and Raghavan, S and Narayanan, S and Shee, S and Singh, A and Varshney, U and Gopal, B and Vijayan, M (2022) Structural variability of Mycobacterium tuberculosis SSB and susceptibility to inhibition. In: Current Science, 122 (3). pp. 281-289.

Datta, M and Singh, J and Modak, MJ and Pillai, M and Varshney, U (2022) Systematic evolution of initiation factor 3 and the ribosomal protein uS12 optimizes Escherichia coli growth with an unconventional initiator tRNA. In: Molecular Microbiology, 117 (2). pp. 462-479.

Singh, J and Mishra, RK and Ayyub, SA and Hussain, T and Varshney, U (2022) The initiation factor 3 (IF3) residues interacting with initiator tRNA elbow modulate the fidelity of translation initiation and growth fitness in Escherichia coli. In: Nucleic Acids Research, 50 (20). pp. 11712-11726.

Mehta, A and Raj, P and Sundriyal, S and Gopal, B and Varshney, U (2021) Use of a molecular beacon based fluorescent method for assaying uracil DNA glycosylase (Ung) activity and inhibitor screening. In: Biochemistry and Biophysics Reports, 26 .

Shetty, S and Varshney, U (2021) Regulation of translation by one-carbon metabolism in bacteria and eukaryotic organelles. In: Journal of Biological Chemistry, 296 .

Ray, U and Sharma, S and Kapoor, I and Kumari, S and Gopalakrishnan, V and Vartak, SV and Kumari, N and Varshney, U and Raghavan, SC (2021) G4 DNA present at human telomeric DNA contributes toward reduced sensitivity to γ-radiation induced oxidative damage, but not bulky adduct formation. In: International Journal of Radiation Biology .

Datta, M and Pillai, M and Modak, MJ and Liiv, A and Khaja, FT and Hussain, T and Remme, J and Varshney, U (2020) A mutation in the ribosomal protein uS12 reveals novel functions of its universally conserved PNSA loop. In: Molecular Microbiology . (In Press)

Raj, P and Karthik, S and Arif, SM and Varshney, U and Vijayan, M (2020) Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1. In: Acta Crystallographica Section D: Structural Biology, 76 . pp. 982-992.

Kapoor, I and Varshney, U (2020) Diverse roles of nucleoside diphosphate kinase in genome stability and growth fitness. In: Current Genetics, 66 (4). pp. 671-682.

Tharp, JM and Krahn, N and Varshney, U and Soll, D (2020) Hijacking Translation Initiation for Synthetic Biology. In: ChemBioChem, 21 (10). pp. 1387-1396.

Sah, S and Lahry, K and Talwar, C and Singh, S and Varshney, U (2020) Monomeric NADH-oxidizing methylenetetrahydrofolate reductases from mycobacterium smegmatis lack flavin coenzyme. In: Journal of Bacteriology, 202 (12).

Kurthkoti, K and Kumar, P and Sang, PB and Varshney, U (2020) Base excision repair pathways of bacteria: New promise for an old problem. In: Future Medicinal Chemistry, 12 (4). pp. 339-355.

Lahry, K and Gopal, A and Sah, S and Shah, RA and Varshney, U (2020) Metabolic Flux of N10-Formyltetrahydrofolate Plays a Critical Role in the Fidelity of Translation Initiation in Escherichia coli. In: Journal of Molecular Biology .

Ravi, V and Jain, A and Khan, D and Ahamed, F and Mishra, S and Giri, M and Inbaraj, M and Krishna, S and Sarikhani, M and Maity, S and Kumar, S and Shah, RA and Dave, P and Pandit, AS and Rajendran, R and Desingu, PA and Varshney, U and Das, S and Kolthur-Seetharam, U and Rajakumari, S and Singh, M and Sundaresan, NR (2019) SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activity. In: Nucleic Acids Research, 47 (17). pp. 9115-9131.

Shah, RA and Varada, R and Sah, S and Shetty, S and Lahry, K and Singh, S and Varshney, U (2019) Rapid formylation of the cellular initiator tRNA population makes a crucial contribution to its exclusive participation at the step of initiation. In: Nucleic acids research, 47 (4). pp. 1908-1919.

Govindan, A and Ayyub, SA and Varshney, U (2018) Sustenance of Escherichia coli on a single tRNAMet. In: Nucleic acids research, 46 (21). pp. 11566-11574.

Ayyub, SA and Aswathy, SL and Dobriyal, D and Aluri, S and Spremulli, LL and Varshney, U (2018) Fidelity of translation in the presence of mammalian mitochondrial initiation factor 3. In: Mitochondrion, 39 . pp. 1-8.

Arif, SM and Patil, AG and Varshney, U and Vijayan, M (2017) Biochemical and structural studies of Mycobacterium smegmatis MutT1, a sanitization enzyme with unusual modes of association. In: ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 73 (4). pp. 349-364.

Arif, SM and Varshney, U and Vijayan, M (2017) Hydrolysis of diadenosine polyphosphates. Exploration of an additional role of Mycobacterium smegmatis MutT1. In: JOURNAL OF STRUCTURAL BIOLOGY, 199 (3). pp. 165-176.

Arif, SM and Geethanandan, K and Mishra, P and Surolia, A and Varshney, U and Vijayan, M (2015) Structural plasticity in Mycobacterium tuberculosis uracil-DNA glycosylase (MtUng) and its functional implications. In: ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 71 (7). pp. 1514-1527.

Selvaraj, M and Govindan, A and Seshadri, A and Dubey, B and Varshney, U and Vijayan, M (2013) Molecular flexibility of Mycobacterium tuberculosis ribosome recycling factor and its functional consequences: An exploration involving mutants. In: JOURNAL OF BIOSCIENCES, 38 (5). pp. 845-855.

Arif, SM and Patil, AG and Varshney, U and Vijayan, M (2012) Crystallization and preliminary X-ray studies of MutT1 (MSMEG_2390) from Mycobacterium smegmatis. In: ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 68 (Part 1). pp. 1214-1216.

Kapoor, S and Samhita, L and Varshney, U (2011) Functional Significance of an Evolutionarily Conserved Alanine (GCA) Resume Codon in tmRNA in Escherichia coli. In: Journal of Bacteriology, 193 (14). pp. 3569-3576. ISSN 0021-9193

Seshadri, A and Dubey, B and Weber, MHW and Varshney, U (2009) Impact of rRNA methylations on ribosome recycling and fidelity of initiation in Escherichia coli. In: Molecular Microbiology, 72 (3). pp. 795-808.

Selvaraj, M and Roy, S and Singh, NS and Sangeetha, R and Varshney, U and Vijayan, M (2007) Structural plasticity and enzyme action: Crystal structures of Mycobacterium tuberculosis peptidyl-tRNA hydrolase. In: Journal of Molecular Biology, 372 (1). pp. 186-193.

Saikrishnan, K and Kalapala, SK and Varshney, U and Vijayan, M (2005) X-ray structural studies of Mycobacterium tuberculosis RRF and a comparative study of RRFs of known structure. Molecular plasticity and biological implications. In: Journal of Molecular Biology, 345 (1). pp. 29-38.

Singh, NS and Das, G and Seshadri, A and Sangeetha, R and Varshney, U (2005) Evidence for a role of initiation factor 3 in recycling of ribosomal complexes stalled on mRNAs in Escherichia coli. In: Nucleic Acids Research, 33 (17). pp. 5591-5601.

Varshney, U and Ramesh, V and Madabushi, A and Gaur, R and Subramanya, HS and RajBhandary, UL (2004) Mycobacterium tuberculosis Rv2118c codes for single-component homotetrameric $m^1A58$ tRNA methyltransferase. In: Nucleic Acids Research, 32 (3). pp. 1018-1027.

Saikrishnan, K and Kalapala, SK and Sagar, Bidya M and Rao, AR and Varshney, U and Vijayan, M (2004) Purification, crystallization and preliminary X-ray studies of Mycobacterium tuberculosis RRF. In: Acta Crystallographica Section D, 60 . pp. 368-370.

Saikrishnan, K and Jeyakanthan, J and Venkatesh, J and Acharya, N and Sekar, K and Varshney, U and Vijayan, M (2003) Structure of Mycobacterium tuberculosis Singlestranded DNA-binding Protein. Variability in Quaternary Structure and Its Implications. In: Journal of Molecular Biology, 331 (2). pp. 385-393.

Saikrishnan, K and Sagar, Bidya M and Ravishankar, R and Roy, S and Purnapatre, K and Handa, P and Varshney, U and Vijayan, M (2002) Domain closure and action of uracil DNA glycosylase (UDG): structures of new crystal forms containing the Escherichia coli enzyme and a comparative study of the known structures involving UDG. In: Acta Crystallographica Section D: Biological Crystallography, 58 (8). pp. 1269-1276.

Saikrishnan, K and Jeyakanthan, J and Venkatesh, J and Acharya, N and Purnapatre, K and Sekar, K and Varshney, U and Vijayan, M (2002) Crystallization and preliminary X-ray studies of the single-stranded DNA-binding protein from Mycobacterium tuberculosis. In: Acta Crystallographica Section D, 58 . pp. 327-329.

Dastur, A and Varshney, U (2001) Promoter analysis in mycobacteria using xy/E reporter assays and its implication in high throughput screening. In: Tuberculosis, 81 (4). pp. 267-269.

Sivagami, AV and Rao, Rajeswara A and Varshney, U (2000) A simple and cost-effective method for preparing DNA from the hard tooth tissue, and its use in polymerase chain reaction amplification of amelogenin gene segment for sex determination in an Indian population. In: Forensic Science International, 110 (2). pp. 107-115.

Vasanthakrishna, M and Rumpal, N and Varshney, U (1998) Organization and copy number of initiator tRNA genes in slow- and fast-growing mycobacteria. In: Journal of Biosciences, 23 (02). pp. 101-110.

Handa, P and Varshney, U (1998) Rapid and reliable site directed mutagenesis using Kunkel's approach. In: Indian Journal of Biochemistry and Biophysics, 35 (02). pp. 63-66.

Ravishankar, R and Sagar, Bidya M and Roy, S and Purnapatre, K and Handa, P and Varshney, U and Vijayan, M (1998) X-Ray analysis of a complex of Escherichia Coli uracil DNA glycosylase(EcUDG) with a proteinaceous inhibitor. The structure elucidation of a prokaryotic UDG. In: Nucleic Acids Research, 26 (21). pp. 4880-4887.

Vasanthakrishna, M and Kumar, NV and Varshney, U (1997) Characterization of the initiator tRNA gene locus and identification of a strong promoter from Mycobacterium tuberculosis. In: Microbiology, 143 (11). pp. 3591-3598.

Kumar, N Vinay and Varshney, U (1997) Contrasting effects of single stranded DNA binding protein on the activity of uracil DNA glycosylase from Escherichia coli towards different DNA substrates. In: Nucleic Acids Research, 25 (12). pp. 2336-2343.

Kumar, NV and Varshney, U (1994) Excision of uracil from the ends of double stranded DNA by uracil DNA glycosylase and its use in high efficiency cloning of PCR products. In: Current science (Bangalore), 67 (9-10). 728 -734.

Kumar, NV and Varshney, U (1994) Inefficient excision of uracil from loop regions of DNA oligomers by E.coli uracil DNA glycosylase. In: Nucleic acids research, 22 (18). pp. 3737-3741.

Editorials/Short Communications

Singh, A and Varshney, U and Vijayan, M (2017) Characterization of a second Single Stranded DNA Binding protein from Mycobacterium smegmatis. In: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 46 (1). S147.

Varshney, U (1994) Nobel Prize for Chemistry. In: Current Science (Bangalore), 66 (1). pp. 6-7.

This list was generated on Fri Apr 26 02:13:59 2024 IST.