Jain, A and Hasan, J and Ravi, V and Muhamed, J and Chatterjee, K and Sundaresan, NR (2018) Engineered biomaterial surfaces for neonatal murine cardiomyocyte culture toward understanding cardiac hypertrophy. In: Trends in Biomaterials and Artificial Organs, 32 (1). pp. 36-39.
Full text not available from this repository.Abstract
Cardiovascular diseases are a major cause of mortality worldwide. There is a large need to develop in vitro platforms that mimic the tissue environment to understand the molecular basis of these cardiovascular diseases. Towards that objective, specifically in the current study, we aim to develop surface engineering strategies to support the growth of neonatal cardiomyocytes. The ECM is known to provide both topographical and biochemical cues to maintain homeostasis. Two different approaches were investigated to modify the surface for culturing neonatal cardiomyocytes, which in turn could be used for investigating cardiac hypertrophy in vitro. Firstly, we have used keratin derived from human hair to develop a simple, efficient and cost-effective protocol for culturing the neonatal cardiomyocytes. Secondly, we also demonstrate that microscale topography can be used to drive arrangement of cells that mimic their organization in vivo and improve cardiac function.
| Item Type: | Journal Article |
|---|---|
| Publication: | Trends in Biomaterials and Artificial Organs |
| Publisher: | Society for Biomaterials and Artificial Organs - India |
| Additional Information: | The copyright for this article belongs to the Society for Biomaterials and Artificial Organs - India |
| Keywords: | Cardiology; Cost effectiveness; Diseases, Cardiac functions; Cardiac hypertrophy; Cardio-vascular disease; Cardiomyocytes; Engineered biomaterials; Microscale topography; Molecular basis; Surface engineering, Pathology |
| Department/Centre: | Division of Biological Sciences > Microbiology & Cell Biology Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy) |
| Date Deposited: | 07 Aug 2022 08:54 |
| Last Modified: | 07 Aug 2022 08:54 |
| URI: | https://eprints.iisc.ac.in/id/eprint/75441 |
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