3D-Printed Silk Proteins for Bone Tissue Regeneration and Associated Immunomodulation

Waidi, YO and Debnath, S and Datta, S and Chatterjee, K (2024) 3D-Printed Silk Proteins for Bone Tissue Regeneration and Associated Immunomodulation. In: Biomacromolecules .

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Abstract

Current bone repair methods have limitations, prompting the exploration of innovative approaches. Tissue engineering emerges as a promising solution, leveraging biomaterials to craft scaffolds replicating the natural bone environment, facilitating cell growth and differentiation. Among fabrication techniques, three-dimensional (3D) printing stands out for its ability to tailor intricate scaffolds. Silk proteins (SPs), known for their mechanical strength and biocompatibility, are an excellent choice for engineering 3D-printed bone tissue engineering (BTE) scaffolds. This article comprehensively reviews bone biology, 3D printing, and the unique attributes of SPs, specifically detailing criteria for scaffold fabrication such as composition, structure, mechanics, and cellular responses. It examines the structural, mechanical, and biological attributes of SPs, emphasizing their suitability for BTE. Recent studies on diverse 3D printing approaches using SPs-based for BTE are highlighted, alongside advancements in their 3D and four-dimensional (4D) printing and their role in osteo-immunomodulation. Future directions in the use of SPs for 3D printing in BTE are outlined. © 2024 American Chemical Society.

Item Type:	Editorials/Short Communications
Publication:	Biomacromolecules
Publisher:	American Chemical Society
Additional Information:	The copyright for this article belongs to American Chemical Society.
Keywords:	Biocompatibility; Bone; Cell engineering; Cell proliferation; Proteins; Scaffolds (biology); Tissue regeneration, 'current; 3-D printing; 3D-printing; Bone repair; Bone tissue engineering; Bone tissue regeneration; Immuno modulations; Mechanical; Repair methods; Silk proteins, 3D printing, biomaterial, biocompatibility; bone remodeling; bone tissue; cell differentiation; human; immunomodulation; immunotherapy; nonhuman; pharmaceutics; review; silk; three dimensional printing; tissue engineering; tissue regeneration
Department/Centre:	Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	09 Sep 2024 10:59
Last Modified:	09 Sep 2024 10:59
URI:	http://eprints.iisc.ac.in/id/eprint/85984

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