Biswas, A and Maitra, U (2022) Ratiometric rapid distinction of two structurally similar fluoroquinolone antibiotics by a Tb/Eu hydrogel. In: RSC Advances, 12 (40). pp. 26106-26110.
|
PDF
RSC_adv_ 12-40_26106 - 26110_2022.pdf - Published Version Download (493kB) | Preview |
Abstract
Norfloxacin and ofloxacin are two frequently prescribed second-generation fluoroquinolone antibiotics with an identical 4-quinolone chromophore and hence, are difficult to distinguish by conventional methods (UV or fluorescence). We have designed a Tb3+/Eu3+/cholate cocktail that enabled us to differentiate these two drugs and rapidly measure their concentrations when present together. Additionally, a Tb3+-cholate gel-based paper sensor was developed to detect and quantify them in a single drug containing system with a limit of detection (LOD) well below 100 nM.
| Item Type: | Journal Article |
|---|---|
| Publication: | RSC Advances |
| Publisher: | Royal Society of Chemistry |
| Additional Information: | The copyright for this article belongs to the Author(s). |
| Keywords: | Antibiotics, Conventional methods; Fluoroquinolone antibiotics; Gel-based; Limit of detection; Norfloxacin; Ofloxacin; Quinolones; Ratiometric; Second generation, Chromophores |
| Department/Centre: | Division of Chemical Sciences > Organic Chemistry |
| Date Deposited: | 07 Nov 2022 10:00 |
| Last Modified: | 07 Nov 2022 10:00 |
| URI: | https://eprints.iisc.ac.in/id/eprint/77770 |
Actions (login required)
 |
View Item |
