An Insight into Anticancer Bioactives from Punica granatum (Pomegranate)

Sharma, K and Kesharwani, P and Prajapati, SK and Jain, A and Jain, D and Mody, N and Sharma, S (2022) An Insight into Anticancer Bioactives from Punica granatum (Pomegranate). In: Anti-Cancer Agents in Medicinal Chemistry, 22 (4). pp. 694-702.

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Abstract

Cancer is one of the major reasons for mortality across the globe. Many side-effects are associated with the formulations available in the market, affecting the quality of life of the patients. This has caused the researchers to find an alternative source of medications, such as herbal medicine, showing a promising effect in anticancer treatment; one such source is Pomegranate, which belongs to the family Punicaceae. Punica granatum contains many polyphenols that have antioxidant, antidiabetic, and therapeutic effects in the treatment and management of metabolic and cardiovascular diseases, as well as a favourable effect on anticancer therapy. Polyphenols like punicalin, punicalagin, and ellagic acid are a few of the many compounds responsible for the anticancer activity of pomegranate. Many preparations of pomegranate, such as Pomegranate Juice (PJ), Pomegranate Seed Oil (PSO), Pomegranate peel extract (PoPx), etc. are used in various clinical studies. These polyphenols show anticancer activity by either arresting the cell cycle in the G2/M phase, inducing apoptosis or damaging the DNA of tumor cells. This review explicitly discusses the role and mechanism of bioactives obtained from the pomegranate in the treatment and management of cancer. The chemical structure, properties, and role of pomegranate in the treatment of breast, lung, thyroid, colon, and prostate cancer have been focused on in detail. This review also discusses various targeted drug delivery approaches for tumour treatment as well as patented preparation of pomegranate compounds along with the ongoing clinical trials.

Item Type:	Journal Article
Publication:	Anti-Cancer Agents in Medicinal Chemistry
Publisher:	Bentham Science Publishers
Additional Information:	The copyright for this article belongs to Bentham Science Publishers.
Keywords:	alkaloid; alpha tocopherol; anthocyanin; antioxidant; apigenin; campesterol; caspase 3; curcumin; ellagic acid; epidermal growth factor receptor; flavonoid; folic acid; galectin 3; gelatinase B; interleukin 17; liposome; lipoxygenase; polyphenol; pomegranate extract; prostate specific antigen; protein p53; quercetin; resveratrol; stigmasterol; vasculotropin; plant extract, angiogenesis; antidiabetic activity; antineoplastic activity; antioxidant activity; antiproliferative activity; apoptosis; blood brain barrier; breast cancer; cancer cell; cancer growth; cancer therapy; cell cycle arrest; cell cycle G2 phase; cell cycle M phase; cell invasion; cell proliferation; cell survival; colon cancer; colorectal cancer; cytotoxicity; drug delivery system; drug formulation; drug release; drug therapy; encapsulation; endometrium cancer; G2 phase cell cycle checkpoint; genotype; herbal medicine; human; liver cell carcinoma; lung cancer; Lythraceae; melanoma; metabolism; nonhuman; oxidative stress; pomegranate; pomegranate juice; prostate cancer; quality of life; rectum cancer; Review; signal transduction; stomach ulcer; Th17 cell; thyroid cancer; tumor cell; tumor growth; ultra performance liquid chromatography; upregulation; chemistry; Lythraceae; male; neoplasm, Humans; Lythraceae; Male; Neoplasms; Plant Extracts; Polyphenols; Pomegranate; Quality of Life
Department/Centre:	Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	26 Jun 2022 07:42
Last Modified:	12 Sep 2022 06:18
URI:	https://eprints.iisc.ac.in/id/eprint/73882

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