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Heterogeneous Host–Pathogen Encounters Coordinate Antibiotic Resilience in Mycobacterium tuberculosis

Mishra, R and Yadav, V and Guha, M and Singh, A (2021) Heterogeneous Host–Pathogen Encounters Coordinate Antibiotic Resilience in Mycobacterium tuberculosis. In: Trends in Microbiology, 29 (7). pp. 606-620.

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Official URL: https://doi.org/10.1016/j.tim.2020.10.013


Successful treatment of tuberculosis (TB) depends on the eradication of its causative agent Mycobacterium tuberculosis (Mtb) in the host. However, the emergence of phenotypically drug-resistant Mtb in the host environment tempers the ability of antibiotics to cure disease. Host immunity produces diverse microenvironmental niches that are exploited by Mtb to mobilize adaptation programs. Such differential interactions amplify pre-existing heterogeneity in the host–pathogen milieu to influence disease pathology and therapy outcome. Therefore, comprehending the intricacies of phenotypic heterogeneity can be an empirical step forward in potentiating drug action. With this goal, we review the interconnectedness of the lesional, cellular, and bacterial heterogeneity underlying phenotypic drug resistance. Based on this information, we anticipate the development of new therapeutic strategies targeting host–pathogen heterogeneity to cure TB.

Item Type: Journal Article
Publication: Trends in Microbiology
Publisher: Elsevier Ltd
Additional Information: The copyright for this article belongs to the Authors.
Keywords: aminoglycoside; gamma interferon; granulocyte macrophage colony stimulating factor; interleukin 1; interleukin 12; interleukin 6; reactive oxygen metabolite; tuberculostatic agent; tumor necrosis factor; tuberculostatic agent, antibiotic resistance; bacterial cell; bacterial gene; bacterial growth; bacterial strain; bacterial transmission; bacterium identification; cell heterogeneity; cellular immunity; host pathogen interaction; host resistance; human; infection control; microbial diversity; Mycobacterium tuberculosis; nonhuman; phenotype; protein expression; Review; signal transduction; sputum analysis; tuberculosis; animal; antibiotic resistance; complication; drug effect; genetics; growth, development and aging; host pathogen interaction; Human immunodeficiency virus infection; immunology; microbiology; mouse; Mycobacterium tuberculosis; tuberculosis, Animals; Antibiotics, Antitubercular; Drug Resistance, Bacterial; HIV Infections; Host-Pathogen Interactions; Humans; Mice; Mycobacterium tuberculosis; Phenotype; Tuberculosis
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Division of Biological Sciences > Centre for Infectious Disease Research
Date Deposited: 05 Jun 2023 09:21
Last Modified: 05 Jun 2023 09:21
URI: https://eprints.iisc.ac.in/id/eprint/81785

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