Polyamine synthesis and salvage pathways in the malaria parasite Plasmodium falciparum

Ramya, TNC and Surolia, Namita and Surolia, Avadhesha (2006) Polyamine synthesis and salvage pathways in the malaria parasite Plasmodium falciparum. In: Biochemical and Biophysical Research Communications, 348 (2). pp. 579-584.

PDF Polyamine_synthesis_and_salvage_pathways_in_the_malaria_parasite.pdf Restricted to Registered users only Download (297kB) | Request a copy

Abstract

We demonstrate, for the first time, a functional polyamine biosynthetic pathway in the malaria parasite Plasmodium falciparum that culminates in the synthesis of spermine. Additionally, we also report putrescine and spermidine salvage in the malaria parasite. Putrescine and spermidine transport in P. falciparum infected red blood cells is a highly specific, carrier mediated and active process, mediated by new transporters that differ from the transporters of uninfected red blood cells in their kinetic parameters, $V_{max}$ and $k_m$, as well as in their activation energy.

Item Type:	Journal Article
Publication:	Biochemical and Biophysical Research Communications
Publisher:	Elseveir.
Additional Information:	Copyright of this article belongs to Elsevier.
Keywords:	Polyamine biosynthesis;Polyamine transport;Plasmodium falciparum;Putrescine;Spermidine;Spermine
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	27 Nov 2007
Last Modified:	19 Sep 2010 04:32
URI:	http://eprints.iisc.ac.in/id/eprint/8789

Actions (login required)

View Item