Interference without interferon: interferon-independent induction of interferon-stimulated genes and its role in cellular innate immunity

Swaraj, S and Tripathi, S (2024) Interference without interferon: interferon-independent induction of interferon-stimulated genes and its role in cellular innate immunity. In: mBio, 15 (10). e0258224.

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Abstract

Interferons (IFNs) are multifaceted proteins that play pivotal roles in orchestrating robust antiviral immune responses and modulating the intricate landscape of host immunity. The major signaling pathway activated by IFNs is the JAK/STAT (Janus kinase/signal transducer and activator of transcription) pathway, which leads to the transcription of a battery of genes, collectively known as IFN-stimulated genes (ISGs). While the well-established role of IFNs in coordinating the innate immune response against viral infections is widely acknowledged, recent years have provided a more distinct comprehension of the functional significance attributed to non-canonical, IFN-independent induction of ISGs. In this review, we summarize the non-conventional signaling pathways of ISG induction. These alternative pathways offer new avenues for developing antiviral strategies or immunomodulation in various diseases.

Item Type:	Journal Article
Publication:	mBio
Additional Information:	The copyright for this article belongs to the author.
Keywords:	interferon; Janus kinase; STAT protein, animal; genetics; human; immunology; innate immunity; metabolism; signal transduction; virus infection, Animals; Humans; Immunity, Innate; Interferons; Janus Kinases; Signal Transduction; STAT Transcription Factors; Virus Diseases
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology Division of Biological Sciences > Centre for Infectious Disease Research
Date Deposited:	19 Nov 2024 20:37
Last Modified:	19 Nov 2024 20:37
URI:	http://eprints.iisc.ac.in/id/eprint/86752

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