Mishra, P and Narayanan, R (2022) Conjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells. In: iScience, 25 (3).
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Abstract
Plasticity in the brain is ubiquitous. How do neurons and networks encode new information and simultaneously maintain homeostasis in the face of such ubiquitous plasticity? Here, we unveil a form of neuronal plasticity in rat hippocampal granule cells, which is mediated by conjunctive changes in HCN, inward-rectifier potassium, and persistent sodium channels induced by theta-modulated burst firing, a behaviorally relevant activity pattern. Cooperation and competition among these simultaneous changes resulted in a unique physiological signature: sub-threshold excitability and temporal summation were reduced without significant changes in action potential firing, together indicating a concurrent enhancement of supra-threshold excitability. This form of intrinsic plasticity was dependent on calcium influx through L-type calcium channels and inositol trisphosphate receptors. These observations demonstrate that although brain plasticity is ubiquitous, strong systemic constraints govern simultaneous plasticity in multiple components�referred here as plasticity manifolds�thereby providing a cellular substrate for concomitant encoding and homeostasis in engram cells. © 2022 The Author(s)
| Item Type: | Journal Article |
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| Publication: | iScience |
| Publisher: | Elsevier Inc. |
| Additional Information: | The copyright for this article belongs to Authors |
| Department/Centre: | Division of Biological Sciences > Molecular Biophysics Unit |
| Date Deposited: | 21 Mar 2022 07:36 |
| Last Modified: | 21 Mar 2022 07:36 |
| URI: | http://eprints.iisc.ac.in/id/eprint/71569 |
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