Heterogeneous Host�Pathogen Encounters Coordinate Antibiotic Resilience in Mycobacterium tuberculosis

Mishra, R and Yadav, V and Guha, M and Singh, A (2020) Heterogeneous Host�Pathogen Encounters Coordinate Antibiotic Resilience in Mycobacterium tuberculosis. In: Trends in Microbiology . (In Press)

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Abstract

Successful treatment of tuberculosis (TB) depends on the eradication of its causative agent Mycobacterium tuberculosis (Mtb) in the host. However, the emergence of phenotypically drug-resistant Mtb in the host environment tempers the ability of antibiotics to cure disease. Host immunity produces diverse microenvironmental niches that are exploited by Mtb to mobilize adaptation programs. Such differential interactions amplify pre-existing heterogeneity in the host�pathogen milieu to influence disease pathology and therapy outcome. Therefore, comprehending the intricacies of phenotypic heterogeneity can be an empirical step forward in potentiating drug action. With this goal, we review the interconnectedness of the lesional, cellular, and bacterial heterogeneity underlying phenotypic drug resistance. Based on this information, we anticipate the development of new therapeutic strategies targeting host�pathogen heterogeneity to cure TB. © 2020 Elsevier Ltd

Item Type:	Journal Article
Publication:	Trends in Microbiology
Publisher:	Elsevier Ltd
Additional Information:	Copyright to this article belongs to Elsevier Ltd
Keywords:	drug tolerancep henotypic heterogeneityredox metabolismphagosomal acidification
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology Division of Biological Sciences > Centre for Infectious Disease Research
Date Deposited:	29 Jan 2021 07:15
Last Modified:	29 Jan 2021 07:15
URI:	http://eprints.iisc.ac.in/id/eprint/67746

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