Evolution of Neutralization Response in HIV-1 Subtype C-Infected Individuals Exhibiting Broad Cross-Clade Neutralization of HIV-1 Strains

Cheedarla, Narayanaiah and Hemalatha, Babu and Anangi, Brahmaiah and Muthuramalingam, Kannan and Selvachithiram, Murugesan and Sathyamurthi, Pattabiraman and Kailasam, Nandagopal and Varadarajan, Raghavan and Swaminathan, Soumya and Tripathy, Srikanth Prasad and Vaniambadi, S Kalyanaraman and Vadakkupattu, D Ramanathan and Hanna, Luke Elizabeth (2018) Evolution of Neutralization Response in HIV-1 Subtype C-Infected Individuals Exhibiting Broad Cross-Clade Neutralization of HIV-1 Strains. In: FRONTIERS IN IMMUNOLOGY, 9 .

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Abstract

Strain-specific neutralizing antibodies develop in all human immunodeficiency virus type 1 (HIV-1)-infected individuals. However, only 10-30% of infected individuals produce broadly neutralizing antibodies (bNAbs). Identification and characterization of these bNAbs and understanding their evolution dynamics are critical for obtaining useful clues for the development of an effective HIV vaccine. Very recently, we published a study in which we identified 12 HIV-1 subtype C-infected individuals from India whose plasma showed potent and broad cross-clade neutralization (BCN) ability (1). In the present study, we report our findings on the evolution of host bNAb response over a period of 4 years in a subset of these individuals. Three of the five individuals (NAB033, NAB059, and NAB065) demonstrated a significant increase (p < 0.05) in potency. Interestingly, two of the three samples also showed a significant increase in CD4 binding site-specific antibody response, maintained stable CD4+ T cell counts (> 350 cells/mm(3)) and continued to remain ART-naive for more than 10 years after initial diagnosis, implying a strong clinical correlation with the development and evolution of broadly neutralizing antibody response against HIV-1.

Item Type:	Journal Article
Publication:	FRONTIERS IN IMMUNOLOGY
Additional Information:	Copy right for this article belong to FRONTIERS MEDIA SA, AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	14 Apr 2018 18:50
Last Modified:	14 Apr 2018 18:50
URI:	http://eprints.iisc.ac.in/id/eprint/59573

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