Ribosome inactivating proteins and apoptosis

Narayanan, Sriram and Surendranath, Kalpana and Bora, Namrata and Surolia, Avadhesha and Karande, Anjali A (2005) Ribosome inactivating proteins and apoptosis. In: FEBS letters, 579 (6). pp. 1324-1331.

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Abstract

Ribosome inactivating proteins (RIPs) are protein toxins that are of plant or microbial origin that inhibit protein synthesis by inactivating ribosomes. Recent studies suggest that RIPs are also capable of inducing cell death by apoptosis. Though many reports are available on cell death induced by RIPs, the mechanism involved is not well studied. Comparison of pathways of apoptosis and cellular events induced by various RIPs suggests a central role played by mitochondria, probably acting as an integrator of cellular stress and cell death. The purpose of this review is to compare the various apoptotic pathways that may be involved and propose a general pathway in RIP-induced cell death.

Item Type:	Journal Article
Publication:	FEBS letters
Publisher:	Elsevier
Additional Information:	The Copyright belongs to Federation of European Biochemical Societies.
Keywords:	Ribosome inactivating protein;Protein synthesis inhibition;Ribosome inactivation;Ribotoxic stress response;Mitochondrial stress;Apoptosis
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit Division of Biological Sciences > Biochemistry
Date Deposited:	28 Feb 2006
Last Modified:	19 Sep 2010 04:24
URI:	http://eprints.iisc.ac.in/id/eprint/5674

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