Nagarajaram, HA and Paul, PKC and Ramanarayanan, K and Soman, KV and Ramakrishnan, C (1992) Conformational studies on beta-bend containing a cis peptide unit. In: International Journal of Peptide & Protein Research, 40 (5). pp. 383-394.
Full text not available from this repository. (Request a copy)Abstract
Conformational studies have been carried out on the X-cis-Pro tripeptide system (a system of three linked peptide units, in the trans-cis-trans configuration) using energy minimization techniques. For X, residues Gly, L-Ala, D-Ala and L-Pro have been used. The energy minima have been classified into different groups based upon the conformational similarity. There are 15, 20, 18 and 6 minima that are possible for the four cases respectively and these fall into 11 different groups. A study of these minima shows that, (i) some minima contain hydrogen bonds - either 4-->1 or 1-->2 type, (ii) the low energy minima qualify themselves as bend conformations, (iii) cis' and trans' conformations are possible for the prolyl residue as also the C(gamma)-endo and C(gamma)-exo puckerings, and (iv) for Pro-cis-Pro, cis' at the first prolyl residue is ruled out, due to the high energy. The available crystal structure data on proteins and peptides, containing cis-Pro segment have been examined with a view to find the minima that occur in solid state. The data from protein show that they fall under two groups. The conformation at X in X-cis-Pro is near extended when it is a non-glycyl residue. In both peptides and proteins there exists a preference for trans' conformation at prolyl residue over cis' when X is a non-glycyl residue. The minima obtained can be useful in modelling studies.
| Item Type: | Journal Article |
|---|---|
| Publication: | International Journal of Peptide & Protein Research |
| Publisher: | Munksgaard Int Publ Ltd, |
| Additional Information: | Copyright of this article belongs to Munksgaard Int Publ Ltd. |
| Keywords: | Bends, Beta; Cis-Prolyl, In Proteins, In Peptides; Conformation, Peptides;Energy Minimization;Hydrogen Bonds With Cis Units;Peptides, Cis Units;Tripeptides With Cis Units. |
| Department/Centre: | Division of Biological Sciences > Molecular Biophysics Unit |
| Date Deposited: | 25 Jan 2011 06:04 |
| Last Modified: | 25 Jan 2011 06:04 |
| URI: | http://eprints.iisc.ac.in/id/eprint/35148 |
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