Bardi, R and Piazzesi, AM and Toniolo, C and Sukumar, M and Balaram, P (1986) Stereochemistry of Peptides Containing 1-Aminocyclopentanecarboxylic Acid $({Acc}^5)$ : Solution and Solid-state Conformations of $Boc-{Acc}^5-{Acc}^5-NHMe$. In: Biopolymers, 25 (9). pp. 1635-1644.
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Abstract
The conformational analysis of a protected homodipeptide of 1-aminocyclopentanecarboxylic acid $({Acc}^5)$ has been carried out. 'H-nmr studies establish a \beta-turn conformation for $Boc-{Acc}^5-{Acc}^5-NHMe$ in chloroform and dimethylsulfoxide solutions involving the methylamide NH in an intramolecular hydrogen bond. Supportive evidence for the formation of an intramolecular hydrogen bond is obtained from ir studies. X-ray diffraction studies reveal a type III \beta-turn conformation in the solid state stabilized by a 4 \rightarrow 1 hydrogen bond between the Boc CO and methylamide NH groups. The \phi, \psi values for both ${Acc}^5$ residues are close to those expected for an ideal $3_{10}$-helical conformation (\phi = \pm 60 deg, \psi = \pm 30 deg).
Item Type: | Journal Article |
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Publication: | Biopolymers |
Publisher: | John Wiley & Sons, Inc |
Additional Information: | Copyright for this article belongs to John Wiley & Sons, Inc. |
Department/Centre: | Division of Biological Sciences > Molecular Biophysics Unit |
Date Deposited: | 02 Mar 2005 |
Last Modified: | 19 Sep 2010 04:18 |
URI: | http://eprints.iisc.ac.in/id/eprint/2859 |
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