Fibrillogenesis in ADan peptides is inhibited by biphenyl ethers

Surolia, Ira and Chhibber, Manmohan and Sarkar, Debi Prasad and Sinha, Sharmistha (2008) Fibrillogenesis in ADan peptides is inhibited by biphenyl ethers. In: Biochemical and Biophysical Research Communications, 370 (4). pp. 681-686.

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Abstract

In this study, biphenyl ethers of diverse functionality were used to assess their effect on fibrillogenesis of both the oxidized and reduced ADan peptides, in vitro. It was noted that these compounds not only stalled fibrillogenesis but were also able to disrupt pre-formed fibers. The EC50 values for the inhibition of this process lie in the nanomolar range for 50 lM of peptide concentration, indicating the high potency of these compounds as inhibitors. It was found that these compounds impart to the peptides, an a-helical conformation which does not allow them to aggregate and form fibrils. These studies also point out that the transition of peptides through a-helical conformation may be a prelude to the onset of fibrillogenesis for oxADan peptides.

Item Type:	Journal Article
Publication:	Biochemical and Biophysical Research Communications
Publisher:	Elsevier Science
Additional Information:	Copyright belongs to Elsevier Science.
Keywords:	Danish dementia;amyloid;inhibition;fibers;biphenyl ethers.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	21 Jul 2009 10:30
Last Modified:	19 Sep 2010 04:54
URI:	http://eprints.iisc.ac.in/id/eprint/16938

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