Meera, G and Ramesh, N and Brahmachari, Samir K (1989) Zintrons in rat \alpha-lactalbumin gene. In: FEBS Letters, 251 (1-2). pp. 245-249.
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Abstract
The eukaryotic genome is characterised by the occurrence of a large amount of repetitive DNA which exists within and around coding sequences. Random repeats of $(TG)_n$ sequences have been observed in several introns. In this paper we show that $(TG)_{14}$and $(TG)_{24}$ sequences present in the third intron of rat \alpha-lactalbumin gene adopt left-handed Z-helices under varying superhelical densities. The overall sequence of the parent plasmid further influenced the level of supercoiling at which the B to Z transition could be induced in $(TG)_n$ sequences. Such Z-potential intervening sequences. (zintrons) could act as buffers to maintain desired levels of supercoiling near the transcribed sequences.
Item Type: | Journal Article |
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Publication: | FEBS Letters |
Publisher: | Elsevier Science B.V. |
Additional Information: | Copyright of this article belongs to Federation of European Biochemical Societies. |
Keywords: | Lactalbumin, α-;Intron sequence;DNA, Z-;DNA supercoiling;(Rat) |
Department/Centre: | Division of Biological Sciences > Molecular Biophysics Unit |
Date Deposited: | 13 Feb 2008 |
Last Modified: | 19 Sep 2010 04:42 |
URI: | http://eprints.iisc.ac.in/id/eprint/12919 |
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