Synthetic Strategies toward Higher Cocrystals of Some Resorcinols

Roy, S and Gaur, R and Paul, M and Rajkumar, M and Desiraju, GR (2022) Synthetic Strategies toward Higher Cocrystals of Some Resorcinols. In: Crystal Growth and Design .

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Abstract

Higher cocrystal synthesis depends on precise strategic approaches. A total of 32 stoichiometric ternary and quaternary cocrystals based on resorcinol derivatives were achieved using structural inequivalence and shape-size mimicry approaches and are reported here. Along with 28 binary precursors that were also obtained, these 60 cocrystals serve to generalize synthetic strategies toward these ends. A number of large synthon Aufbau modules (LSAMs) were designed depending on the substitution pattern in the resorcinol. The LSAMs from 5-substituted resorcinol were found to be useful in designing higher cocrystals. The construction of a stoichiometric quaternary cocrystal without the "special"compound 2,3,5,6-tetramethylpyrazine has been finally secured. © 2022 American Chemical Society.

Item Type:	Journal Article
Publication:	Crystal Growth and Design
Publisher:	American Chemical Society
Additional Information:	The copyright for this article belongs to American Chemical Society.
Keywords:	Co-crystals; Strategic approaches; Substitution patterns; Synthetic strategies; Synthons, Phenols
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	09 Jan 2023 07:29
Last Modified:	09 Jan 2023 07:29
URI:	https://eprints.iisc.ac.in/id/eprint/78923

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