Chauhan, A and Toley, BJ (2021) BARRIER-FREE PAPER ANALYTICAL DEVICES FOR MULTIPLEX COLORIMETRIC DETECTION. In: 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021, 10 October 2021through 14 October2021, Palm Springs, Virtual, pp. 1345-1346.
Full text not available from this repository.Abstract
Current methods for multiplexed colorimetric detection in microfluidic paper analytical devices (μPADs) require creation of hydrophobic barriers using expensive equipment, posing a challenge for scale-up. In addition, non-uniform rehydration of reagents makes quantification difficult. To overcome these limitations, we present barrier-free μPAD (BF-μPAD), a multiplex colorimetric detection device that does not require patterning barriers. Compared to patterned μPADs, BF-μPADs improve the limit of detection by ~3.7x and produce perfectly uniform colorimetric signals. BF-μPADs consist of a stack of two paper membranes having different wicking rates - the ensuing unique flow patterns that enable barrier-free multiplex detection are modeled using COMSOL. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
| Item Type: | Conference Paper |
|---|---|
| Publication: | MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Publisher: | Chemical and Biological Microsystems Society |
| Additional Information: | The copyright for this article belongs to Chemical and Biological Microsystems Society. |
| Keywords: | multiplex detection; paper microfluidics; partial saturation; uniform rehydration |
| Department/Centre: | Division of Mechanical Sciences > Chemical Engineering |
| Date Deposited: | 03 Oct 2022 04:46 |
| Last Modified: | 06 Oct 2022 05:43 |
| URI: | https://eprints.iisc.ac.in/id/eprint/76686 |
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