A 9-gene biomarker panel identifies bacterial coinfections in culture-negative COVID-19 cases

Banerjee, U and Rao, P and Reddy, M and Hussain, M and Chunchanur, S and Ambica, R and Singh, A and Chandra, N (2022) A 9-gene biomarker panel identifies bacterial coinfections in culture-negative COVID-19 cases. In: Molecular Omics .

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Abstract

Confirmatory diagnosis of bacterial coinfections with COVID-19 is challenging due to the limited specificity of the widely used gold-standard culture sensitivity test despite clinical presentations. A misdiagnosis can either lead to increased health complications or overuse of antibiotics in COVID-19 patients. With a multi-step systems biology pipeline, we have identified a 9-gene biomarker panel from host blood that can identify bacterial coinfection in COVID-19 patients, even in culture-negative cases. We have also formulated a qPCR-based score that diagnoses bacterial coinfection with COVID-19 with the accuracy, specificity, and sensitivity of 0.93, 0.96, and 0.89, respectively. This gene signature and score can assist in the clinical decision-making process of necessary and timely prescription of antibiotics in suspected bacterial coinfection cases with COVID-19 and thereby help to reduce the associated morbidity and mortality. © 2022 The Royal Society of Chemistry.

Item Type:	Journal Article
Publication:	Molecular Omics
Publisher:	Royal Society of Chemistry
Additional Information:	The copyright for this article belongs to Elsevier Science.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	06 Sep 2022 06:58
Last Modified:	06 Sep 2022 06:58
URI:	https://eprints.iisc.ac.in/id/eprint/76467

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