Vitamin-B6 schiff base dioxovanadium(V) complex for targeted visible lightinduced anticancer activity

Kumar, A and Banerjee, S and Mukherjee, S and Chakravarty, AR (2017) Vitamin-B6 schiff base dioxovanadium(V) complex for targeted visible lightinduced anticancer activity. In: Indian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry, 56A (8). pp. 805-813.

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Abstract

A dioxovanadium(V) complex of vitamin-B6 Schiff base VO2L (1) (where H2L·HCl is 3-hydroxy-5-(hydroxymethyl)- 4-(((2-hydroxyphenyl)imino)methyl)-2-methylpyridin-1-ium chloride) has been prepared and structurally characterized. Its photo-induced cytotoxicity and mechanism of cell death has been studied. Single crystal X-ray structure shows five-coordinate square-pyramidal geometry of the complex having the dianionic O,N,O-donor tridentate vitamin-B6 Schiff base and two cis-oriented oxo ligands bound to V(V). DFT study shows the HOMO located on the amino-phenolic moiety, while the LUMO is on the protonated aromatic unit, i.e., the pyridiniumphenolate moiety. Vitamin-B6 transporting membrane carrier (VTC) pathway seems to be responsible for the higher cellular uptake and activity of the complex into the cervical HeLa and breast cancer MCF-7 cells in preference to the normal embryonic fibroblast 3T3 cells. The complex exhibits reactive oxygen species (ROS) mediated apoptotic photocytotoxicity in visible light of 400-700 nm in the cancer cells (IC50: 16 μM), while being essentially non-Toxic in the dark. Alkaline Comet assay shows damage of the nuclear DNA.

Item Type:	Journal Article
Publication:	Indian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry
Publisher:	Council of Scientific Research Integration
Additional Information:	The copyright for this article belongs to the Council of Scientific Research Integration.
Keywords:	Bioinorganic chemistry; Cell apoptosis; Crystal structure; Photocytotoxicity; Schiff base; Vanadium; Vitamin-B6 schiff base
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	17 Jul 2022 06:07
Last Modified:	17 Jul 2022 06:07
URI:	https://eprints.iisc.ac.in/id/eprint/74500

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