Effect of anti-stress activity of buspirone on restrained stress induced male albino rats

Desai, SD and Kori, RS and Aladakatti, RH (2017) Effect of anti-stress activity of buspirone on restrained stress induced male albino rats. In: Journal of Pharmaceutical Sciences and Research, 9 (11). pp. 2068-2071.

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Abstract

Experiments were conducted with the aim of evaluating the protective potential of Buspirone, an anxiolytic drug, on alteration in gravimetry and hematological parameters in male albino rats. 28 adult Wistar albino rats weighing about 175 to 225g were taken for the study and were divided at random into four groups of six animals each. Group I (control), kept undisturbed in the metabolic cage throughout the 42 days experimental period. Group II (stress) rats were kept in a wire mesh restrainer for 6 hr/day for 42 days. Group III (stress+ withdrawal) rats were stressed for 21 days and withdrawal of stress for remaining 21 days (total 42 days). Group IV (stress + Buspirone) rats were only stressed for 21 days and treated with drug Buspirone (12mg/kg body weight, IP) in continuation with stress for remaining 21 days (total period is 42 days). At the end of the study period, all the experimental rats were sacrificed and gravimetrical, hematological parameters were evaluated. Results revealed after 42 days, there was a significant (P ≤0.05) decrease final body weight, Hb, RBC, MCV, MCH, total WBC and Platelets, while increase in neutrophils, lymphocytes, eosinophils and monocytes in Group II of restraint stress rats when compared to control group I. Group III and Group IV shown significantly (P≤0.05) improvement in gravimetry and hematological parameters in restraint stress compared to only group II. Results indicate a possible antioxidant effect of Buspirone on restrained stress induced alteration of gravimetrical and hematological profiles in male albino rats.

Item Type:	Journal Article
Publication:	Journal of Pharmaceutical Sciences and Research
Publisher:	Pharmainfo Publications
Additional Information:	The copyright for this article belongs to the Pharmainfo Publications.
Keywords:	buspirone; methylpentynol, adult; Article; controlled study; emotional stress; food intake; gravimetry; hematologic disease; male; nonhuman; physiological stress; rat; tranquilizing activity; weight gain
Department/Centre:	Division of Biological Sciences > Central Animal Facility (Formerly Primate Research Laboratory)
Date Deposited:	15 Jul 2022 11:37
Last Modified:	15 Jul 2022 11:37
URI:	https://eprints.iisc.ac.in/id/eprint/74459

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