Dutta, S and Mukherjee, A and Nongthomba, U (2022) Before the “cytokine storm”: Boosting efferocytosis as an effective strategy against SARS-CoV-2 infection and associated complications. In: Cytokine and Growth Factor Reviews, 63 . pp. 108-118.
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Abstract
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is responsible for the ongoing COVID-19 pandemic, and causes many health complications, including major lung diseases. Besides investigations into the virology of SARS-CoV-2, understanding the immunological routes underlying the clinical manifestations of COVID-19 is important for developing effective therapeutic interventions. The clearance of SARS-CoV-2-infected apoptotic cells by professional efferocytes, through a process termed as 'efferocytosis', is essential for maintaining tissue homeostasis, and reducing the chances of health complications caused by SARS-CoV-2 infection. In this review, we focus on the cellular events leading to engagement of the SARS-CoV-2 with type 2 alveolar cells, and how SARS-COV-2 infection impairs the macrophage anti-inflammatory programming. We also discuss accounts of impaired efferocytosis, and the “cytokine storm” which occur concomitantly with the SARS-CoV-2 infection. Finally, we propose how targeting impaired efferocytosis, due to the SARS-CoV-2 infection, may be a beneficial therapeutic strategy to combat COVID-19, and its complications.
| Item Type: | Journal Article |
|---|---|
| Publication: | Cytokine and Growth Factor Reviews |
| Publisher: | Elsevier Ltd |
| Additional Information: | The copyright for this article belongs to the Elsevier Ltd. |
| Keywords: | adult respiratory distress syndrome; apoptosis; autoimmune disease; coronavirus disease 2019; cytokine storm; diabetes mellitus; disease association; efferocytosis; human; infection complication; inflammation; lung alveolus cell type 2; lung disease; macrophage; nonhuman; nuclear reprogramming; phagocytosis; respiratory system; Review; Severe acute respiratory syndrome coronavirus 2; virus immunity; cytokine release syndrome; pandemic, COVID-19; Cytokine Release Syndrome; Humans; Macrophages; Pandemics; SARS-CoV-2 |
| Department/Centre: | Division of Biological Sciences > Molecular Reproduction, Development & Genetics |
| Date Deposited: | 27 Jun 2022 05:50 |
| Last Modified: | 27 Jun 2022 05:50 |
| URI: | https://eprints.iisc.ac.in/id/eprint/73904 |
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