Identification of short single disulfide-containing contryphans from the venom of cone snails using de novo mass spectrometry-based sequencing methods

Franklin, Jayaseelan Benjamin and Rajesh, Rajaian Pushpabai and Vinithkumar, Nambali Valsalan and Kirubagaran, Ramalingam (2017) Identification of short single disulfide-containing contryphans from the venom of cone snails using de novo mass spectrometry-based sequencing methods. In: Toxicon, 132 . pp. 50-54. ISSN 00410101

PDF tox_132_50-54_2017 .pdf - Published Version Restricted to Registered users only Download (974kB) | Request a copy

Abstract

We identified 12 short single disulfide-containing conopeptides from the venom of Conus coronatus, C. leopardus, C. lividus and C. zonatus. Interestingly, we detected the shortest contryphan sequence thus far characterized which contains only six amino acid residues. We also identified three distinct contryphan sequences of C. lividus without any proline residues and one sequence with an unusual post-translational modification (bromination of tryptophan). Furthermore, we characterized venom peptides of C. zonatus for the first time.

Item Type:	Journal Article
Publication:	Toxicon
Publisher:	Elsevier Ltd
Additional Information:	The copyright for this article belongs to the Elsevier Ltd.
Keywords:	Cone snails; Conopeptides; Contryphans; Linear peptides; Mass spectrometry; Short conopeptides
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	31 May 2022 05:35
Last Modified:	31 May 2022 05:35
URI:	https://eprints.iisc.ac.in/id/eprint/72903

Actions (login required)

View Item