Microscale engineering of hollow microneedle tips: design, manufacturing, optimization and validation

Badnikar, K and Jayadevi, SN and Pahal, S and Vemula, PK and Nayak, MM and Subramanyam, DN (2022) Microscale engineering of hollow microneedle tips: design, manufacturing, optimization and validation. In: Drug Delivery and Translational Research, 12 (2). pp. 350-367.

PDF dru_del_tra_res_12-2_350-367_2022.pdf - Published Version Restricted to Registered users only Download (9MB) | Request a copy

Abstract

Transdermal and intradermal drug delivery utilizing microneedles is an emerging front in painless therapeutics. Drug delivery using hollow microneedles is the most preferred method for delivering generic transdermal drugs in the clinical setup. The needle tip must be extremely short as the drug is administered to sub-millimeter depths. Also, they need to be sharp enough to pierce through the skin with minimal skin flexing. There are multiple challenges in engineering a tip profile that is short and sharp at the same time. Stainless steel (SS) hypodermic needles with the lancet tip profile are ubiquitous in subcutaneous and intramuscular injections. They have long bevel lengths that make them inappropriate as microneedles. Thus, designing a unique tip profile and developing the manufacturing technology for microneedle applications are necessary. This article presents the design and optimization of microneedle tip profiles through analytical models. Further, manufacturing strategies for reliably obtaining designed profiles are discussed. The article concludes with experimental validation of improved piercing performance of the optimized tip profile compared to other tip profiles. Graphic Abstract: The article discusses about tip geometries of stainless steel needles for microneedle applications, where depth of delivery is less than 1 mm. Through series of analyses, the optimum needle tip geometry evolved from single plane bevel (SPB) to hex plane bevel (HPB) progressively improving piercing performance Figure not available: see fulltext. © 2021, Controlled Release Society.

Item Type:	Journal Article
Publication:	Drug Delivery and Translational Research
Publisher:	Springer
Additional Information:	The copyright for this article belongs to Springer
Department/Centre:	Division of Electrical Sciences > Electronic Systems Engineering (Formerly Centre for Electronic Design & Technology) Division of Interdisciplinary Sciences > Centre for Nano Science and Engineering
Date Deposited:	26 Nov 2021 11:40
Last Modified:	11 Sep 2022 06:23
URI:	https://eprints.iisc.ac.in/id/eprint/70452

Actions (login required)

View Item