Mandal, A and Chatterjee, K (2024) The 3 D/4D Printing of Polymeric Scaffolds for Bone Tissue Engineering. [Book Chapter]
Full text not available from this repository. (Request a copy)Abstract
Three-dimensional (3D) printing can be employed to fabricate customized, on-demand, patient-specific scaffolds for bone tissue repair and regeneration toward the clinical reconstruction of critical-size bone defects resulting from nonunion fractures, congenital diseases, or bone tumor resections. The unprecedented spatial control, resolution, and accuracy in mimicking micro-/macro-scaled features make 3D printing the best-suited biofabrication process for constructing biomimetic designs that incorporate the gradients in composition, density, and porosity present in the native bone. The scaffold materials are typically based on degradable natural and synthetic polymers and often decorated with ceramics, nanomaterials, or bioactive growth factors and/or proteins that render the scaffold osteoinductive and osteoconductive and aid in osseointegration. This chapter provides an in-depth overview of the state-of-the-art advances in the 3D printing/bioprinting of bone tissue scaffolds, with an emphasis on the printing techniques, scaffold design strategies, and material compositions that enable recapitulating the hierarchical architecture and load-bearing capability of the bone tissue. Emerging areas such as intraoperative printing and 4D printing and their applications in orthopedics are also highlighted. Finally, the current limitations and the future directions are summarized. © 2025 selection and editorial matter, Ashok Kumar, Sneha Singh, and Prerna Singh; individual chapters, the contributors.
| Item Type: | Book Chapter |
|---|---|
| Publication: | Emerging Materials and Technologies for Bone Repair and Regeneration |
| Publisher: | CRC Press |
| Additional Information: | The copyright for this article belongs to the publisher. |
| Department/Centre: | Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy) |
| Date Deposited: | 24 Oct 2024 08:25 |
| Last Modified: | 24 Oct 2024 08:25 |
| URI: | http://eprints.iisc.ac.in/id/eprint/86401 |
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