Drug tolerance and persistence in bacteria, fungi and cancer cells: Role of non-genetic heterogeneity

El Meouche, I and Jain, P and Jolly, MK and Capp, J-P (2024) Drug tolerance and persistence in bacteria, fungi and cancer cells: Role of non-genetic heterogeneity. In: Translational Oncology, 49 .

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Abstract

A common feature of bacterial, fungal and cancer cell populations upon treatment is the presence of tolerant and persistent cells able to survive, and sometimes grow, even in the presence of usually inhibitory or lethal drug concentrations, driven by non-genetic differences among individual cells in a population. Here we review and compare data obtained on drug survival in bacteria, fungi and cancer cells to unravel common characteristics and cellular pathways, and to point their singularities. This comparative work also allows to cross-fertilize ideas across fields. We particularly focus on the role of gene expression variability in the emergence of cell-cell non-genetic heterogeneity because it represents a possible common basic molecular process at the origin of most persistence phenomena and could be monitored and tuned to help improve therapeutic interventions. © 2024

Item Type:	Journal Article
Publication:	Translational Oncology
Publisher:	Neoplasia Press, Inc.
Additional Information:	The copyright for this article belongs to Neoplasia Press, Inc.
Department/Centre:	Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited:	10 Sep 2024 04:37
Last Modified:	10 Sep 2024 04:37
URI:	http://eprints.iisc.ac.in/id/eprint/85999

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