Hari, K and Duncan, W and Ibrahim, MA and Jolly, MK and Cummins, B and Gedeon, T (2023) Assessing biological network dynamics: comparing numerical simulations with analytical decomposition of parameter space. In: npj Systems Biology and Applications, 9 (1).
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Abstract
Mathematical modeling of the emergent dynamics of gene regulatory networks (GRN) faces a double challenge of (a) dependence of model dynamics on parameters, and (b) lack of reliable experimentally determined parameters. In this paper we compare two complementary approaches for describing GRN dynamics across unknown parameters: (1) parameter sampling and resulting ensemble statistics used by RACIPE (RAndom CIrcuit PErturbation), and (2) use of rigorous analysis of combinatorial approximation of the ODE models by DSGRN (Dynamic Signatures Generated by Regulatory Networks). We find a very good agreement between RACIPE simulation and DSGRN predictions for four different 2- and 3-node networks typically observed in cellular decision making. This observation is remarkable since the DSGRN approach assumes that the Hill coefficients of the models are very high while RACIPE assumes the values in the range 1-6. Thus DSGRN parameter domains, explicitly defined by inequalities between systems parameters, are highly predictive of ODE model dynamics within a biologically reasonable range of parameters. © 2023, The Author(s).
| Item Type: | Journal Article |
|---|---|
| Publication: | npj Systems Biology and Applications |
| Publisher: | Nature Research |
| Additional Information: | The copyright for this article belongs to authors. |
| Keywords: | computer simulation; gene regulatory network; genetics; theoretical model, Computer Simulation; Gene Regulatory Networks; Models, Theoretical |
| Department/Centre: | Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering |
| Date Deposited: | 29 Nov 2024 10:53 |
| Last Modified: | 29 Nov 2024 10:53 |
| URI: | http://eprints.iisc.ac.in/id/eprint/85351 |
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