Core-Shell Structure of Photopolymer-Grafted Polyurethane as a Controlled Drug Delivery Vehicle for Biomedical Application

Santra, A and Prakash, R and Maity, S and Nilawar, S and Chatterjee, K and Maiti, P (2024) Core-Shell Structure of Photopolymer-Grafted Polyurethane as a Controlled Drug Delivery Vehicle for Biomedical Application. In: ACS Applied Materials and Interfaces, 16 (14). pp. 17193-17207.

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Abstract

Functionalized ultraviolet photocurable bisphenol A-glycerolate dimethacrylates with tailorable size have been synthesized as the core, which have further been grafted using the diisocyanate chain end of polyurethane (PU) as the shell to create a core-shell structure of tunable size for a controlled drug delivery vehicle. The core-shell structure has been elucidated through spectroscopic techniques like 1H NMR, FTIR, and UV-vis and their relative shape and size through TEM and AFM morphology. The greater cross-link density of the core is reflected in the higher glass transition temperature, and the improved thermal stability of the graft copolymer is proven from its thermogravimetric analyses. The flow behavior and enhanced strength of the graft copolymers have been revealed from rheological measurements. The graft copolymer exhibits sustained release of the drug, as compared to pure polyurethane and photopolymer, arising from its core-shell structure and strong interaction between the copolymer and drug, as observed through a significant shifting of absorption peaks in FTIR and UV-vis measurements. Biocompatibility has been tested for the real application of the novel graft copolymer in medical fields, as revealed from MTT assay, cell imaging, and cell adhesion studies. The efficacy of controlled release from a graft copolymer has been verified from the gradual cell killing and �70 killing in 3 days vs meager cell killing of �25 very quickly in 1 day, followed by the increased cell viability of the system treated with the pure drug. The mechanism of slow and controlled drug release from the core-shell structure has been explored. The fluorescence images support the higher cell-killing efficiency as opposed to a pure drug or a drug embedded in polyurethane. Cells seeded on 3D scaffolds have been developed by embedding a graft copolymer, and fluorescence imaging confirms the successful growth of cells within the scaffold, realizing the potential of the core-shell graft copolymer in the biomedical arena. © 2024 American Chemical Society.

Item Type:	Journal Article
Publication:	ACS Applied Materials and Interfaces
Publisher:	American Chemical Society
Additional Information:	The copyright for this article belongs to American Chemical Society.
Keywords:	Biocompatibility; Cell adhesion; Cells; Fluorescence imaging; Glass transition; Graft copolymers; Grafting (chemical); Medical applications; Medical imaging; Polyurethanes; Scaffolds (biology); Shells (structures); Targeted drug delivery; Thermodynamic stability; Thermogravimetric analysis, 3D scaffolds; Biomedical applications; Cell killing; Core shell structure; Drug delivery vehicles; FTIR; Functionalized; Graft- copolymers; Grafted polyurethane; Sustained drug delivery, Controlled drug delivery, drug carrier; polymer; polyurethan, chemistry; drug delivery system; procedures, Drug Carriers; Drug Delivery Systems; Polymers; Polyurethanes
Department/Centre:	Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	10 Jul 2024 08:00
Last Modified:	10 Jul 2024 08:00
URI:	http://eprints.iisc.ac.in/id/eprint/84787

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