Role of surface glycans in enveloped RNA virus infections: A structural perspective

Pandey, B and Srividhya, S and Chatterjee, A and Mangala Prasad, V (2023) Role of surface glycans in enveloped RNA virus infections: A structural perspective. In: Proteins: Structure, Function and Bioinformatics .

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Abstract

Enveloped RNA viruses have been causative agents of major pandemic outbreaks in the recent past. Glycans present on these virus surface proteins are critical for multiple processes during the viral infection cycle. Presence of glycans serves as a key determinant of immunogenicity, but intrinsic heterogeneity, dynamics, and evolutionary shifting of glycans in heavily glycosylated enveloped viruses confounds typical structure�function analysis. Glycosylation sites are also conserved across different viral families, which further emphasizes their functional significance. In this review, we summarize findings regarding structure�function correlation of glycans on enveloped RNA virus proteins. © 2023 Wiley Periodicals LLC.

Item Type:	Journal Article
Publication:	Proteins: Structure, Function and Bioinformatics
Publisher:	John Wiley and Sons Inc
Additional Information:	The copyright for this article belongs to John Wiley and Sons Inc.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit Division of Biological Sciences > Centre for Infectious Disease Research
Date Deposited:	04 Mar 2024 09:24
Last Modified:	04 Mar 2024 09:24
URI:	https://eprints.iisc.ac.in/id/eprint/84290

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