Raghavendra, SM and Kumaraswamy, MN and Nagarsha, KM and Sharanakumar, TM and Ramamurthy, PC and Latha, KP (2023) DESIGN, SYNTHESIS, MOLECULAR DOCKING, AND ANTIMICROBIAL STUDY ON NAPHTHOFURAN DERIVATIVES. In: Rasayan Journal of Chemistry, 16 (3). pp. 1613-1623.
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Abstract
The ethyl-naphtho2,1-bfuron-2-carboxylate 2, hydrazine hydrate in the presence of a catalytic quantity of conc. HCl in ethanol was refluxed at 300 C to get the naphtho2,1-bfuran-2-carbohydrazide 3. The reaction of aromatic acids with methanol in the presence of an acid catalyst gives esters, these esters on treatment with hydrazine hydrazide produce acid hydrazides 4a-f. These acid hydrazides 4a-f, in reaction with carbon disulphide produces 2-(substituted)phenylhydrazine-potassiumcarbodithioate 5a-f. The reaction of 5a-f with compound 3 in ethanol produces N-3-phenyl-5-sulphanyl-4H-1,2,4-triazole-4-yl)-naphtho2,1-b]furan-2-carboxamide 6a-f. Elemental analysis, FTIR, NMR, and mass spectral analyses have been used to characterize the synthesized compounds. They have also been applied to research on antimicrobial studies and have also done the docking investigation of the synthesized compounds with the various biological molecules to get excellent results. © 2023, Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma. All rights reserved.
| Item Type: | Journal Article |
|---|---|
| Publication: | Rasayan Journal of Chemistry |
| Publisher: | Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma |
| Additional Information: | The copyright for this article belongs to author. |
| Department/Centre: | Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy) |
| Date Deposited: | 01 Mar 2024 10:01 |
| Last Modified: | 01 Mar 2024 10:01 |
| URI: | https://eprints.iisc.ac.in/id/eprint/84033 |
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