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Emerging 4D fabrication of next-generation nerve guiding conduits: a critical perspective

Joshi, A and Choudhury, S and Asthana, S and Homer-Vanniasinkam, S and Nambiar, U and Chatterjee, K (2023) Emerging 4D fabrication of next-generation nerve guiding conduits: a critical perspective. In: Biomaterials Science, 11 (24). pp. 7703-7708.

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Official URL: https://doi.org/10.1039/d3bm01299a


The latest advancements in the field of manufacturing for biomedicine, digital health, targeted therapy, and personalized medicine have fuelled the fabrication of smart medical devices. Four-dimensional (4D) fabrication strategies, which combine the manufacturing of three-dimensional (3D) parts with smart materials and/or design, have proved beneficial in creating customized and self-fitting structures that change their properties on demand with time. These frontier techniques that yield dynamic implants can indeed alleviate various drawbacks of current clinical practices, such as the use of sutures and complex microsurgeries and associated inflammation, among others. Among various clinical applications, 4D fabrication has lately made remarkable progress in the development of next-generation nerve-guiding conduits for treating peripheral nerve injuries (PNIs) by improving the end-to-end co-aptation of transected nerve endings. The current perspective highlights the relevance of 4D fabrication in developing state-of-the-art technologies for the treatment of PNIs. Various 4D fabrication/bio-fabrication techniques for PNI treatment are summarized while identifying the challenges and opportunities for the future. Such advancements hold immense promise for improving the quality of life of patients suffering from nerve damage and the potential for extending the treatment of many other disorders. Although the techniques are being described for PNIs, they will lend themselves suitably to certain cases of cranial nerve injuries as well. © 2023 The Royal Society of Chemistry.

Item Type: Journal Article
Publication: Biomaterials Science
Publisher: Royal Society of Chemistry
Additional Information: The copyright for this article belongs to Royal Society of Chemistry.
Keywords: Digital devices; Patient treatment, 'current; Critical perspectives; Fabrication strategies; Nerve injuries; On demands; Peripheral nerves; Personalized medicines; Property; Smart material designs; Smart medical devices, Fabrication, human; nerve regeneration; peripheral nerve injury; personalized medicine; quality of life, Humans; Nerve Regeneration; Peripheral Nerve Injuries; Precision Medicine; Prostheses and Implants; Quality of Life
Department/Centre: Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited: 01 Mar 2024 05:37
Last Modified: 01 Mar 2024 05:37
URI: https://eprints.iisc.ac.in/id/eprint/83808

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