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Mechanobiological Strategies to Augment Cancer Treatment

Kumari, A and Veena, SM and Luha, R and Tijore, A (2023) Mechanobiological Strategies to Augment Cancer Treatment. In: ACS Omega, 8 (45). 42072 -42085.

Acc_ome_8_45_2023.pdf - Published Version

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Official URL: https://doi.org/10.1021/acsomega.3c06451


Cancer cells exhibit aberrant extracellular matrix mechanosensing due to the altered expression of mechanosensory cytoskeletal proteins. Such aberrant mechanosensing of the tumor microenvironment (TME) by cancer cells is associated with disease development and progression. In addition, recent studies show that such mechanosensing changes the mechanobiological properties of cells, and in turn cells become susceptible to mechanical perturbations. Due to an increasing understanding of cell biomechanics and cellular machinery, several approaches have emerged to target the mechanobiological properties of cancer cells and cancer-associated cells to inhibit cancer growth and progression. In this Perspective, we summarize the progress in developing mechano-based approaches to target cancer by interfering with the cellular mechanosensing machinery and overall TME. © 2023 The Authors. Published by American Chemical Society.

Item Type: Journal Article
Publication: ACS Omega
Publisher: American Chemical Society
Additional Information: The copyright for this article belongs to Authors.
Department/Centre: Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 29 Feb 2024 09:17
Last Modified: 29 Feb 2024 09:17
URI: https://eprints.iisc.ac.in/id/eprint/83802

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