Hierarchical porous covalent organic framework-based sensor for the detection of neurodegenerative disorder biomarkers

Rajeev, R and Islam, SS and Varghese, A and Hegde, G and Bose, S (2024) Hierarchical porous covalent organic framework-based sensor for the detection of neurodegenerative disorder biomarkers. In: Materials Chemistry and Physics, 312 .

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Abstract

Guanosine is an essential biomarker that enacts an important role in neuroprotection against brain-related activities, influences the metabolism of fatty acids, and assists in the improvement of the gastrointestinal tract. A facile and selective electrochemical sensor has been developed for the sensing of guanosine based on a hierarchical porous covalent organic framework. Owing to the distinctive 2D porous architecture and ordered framework of TpBD-COF, the irreversible electrooxidation of guanosine occurred at 1.03 V (vs. SCE) in phosphate buffer solution at pH 6. The anodic peak currents under optimal conditions were linear with guanosine concentration within the range of 0.123–720 μM with a LOD of 40.63 nM under various optimal conditions. Moreover, the developed biosensor was used to determine guanosine in pharmaceutical tablets to confirm its potential application in the healthcare industry

Item Type:	Journal Article
Publication:	Materials Chemistry and Physics
Publisher:	Elsevier Ltd
Additional Information:	The copyright for this article belongs to Elsevier Ltd.
Keywords:	Biomolecules; Brain; Carbon fibers; Electrochemical sensors; Electrooxidation; Fatty acids; Neurodegenerative diseases, Carbon fiber paper; Covalent organic frameworks; Electrochemical sensing; Gastrointestinal tract; Guanosines; Hierarchical porous; Neurodegenerative disorders; Neuroprotection; Optimal conditions; Porous architectures, Biomarkers
Department/Centre:	Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	27 Feb 2024 09:48
Last Modified:	27 Feb 2024 09:48
URI:	https://eprints.iisc.ac.in/id/eprint/83611

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