NIR-activated quercetin-based nanogels embedded with CuS nanoclusters for the treatment of drug-resistant biofilms and accelerated chronic wound healing

Nain, A and Tseng, Y-T and Gupta, A and Lin, Y-F and Arumugam, S and Huang, Y-F and Huang, C-C and Chang, H-T (2023) NIR-activated quercetin-based nanogels embedded with CuS nanoclusters for the treatment of drug-resistant biofilms and accelerated chronic wound healing. In: Nanoscale Horizons, 8 (12). pp. 1652-1664.

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Abstract

We have developed multifunctional nanogels with antimicrobial, antioxidant, and anti-inflammatory properties, facilitating rapid wound healing. To prepare the multifunctional nanogels, we utilized quercetin (Qu) and a mild carbonization process to form carbonized nanogels (CNGs). These CNGs possess excellent antioxidative and bacterial targeting properties. Subsequently, we utilized the Qu-CNGs as templates to prepare nanogels incorporating copper sulfide (CuS) nanoclusters, further enhancing their functionality. Notably, the CuS/Qu-CNGs nanocomposites demonstrated an exceptional minimum inhibitory concentration against tested bacteria, approximately 125-fold lower than monomeric Qu or Qu-CNGs. This enhanced antimicrobial effect was achieved by leveraging near-infrared II (NIR-II) light irradiation. Additionally, the CuS/Qu-CNGs exhibited efficient penetration into the extracellular biofilm matrix, eradicating methicillin-resistant Staphylococcus aureus-associated biofilms in diabetic mice wounds. Furthermore, the nanocomposites were found to suppress proinflammatory cytokines, such as IL-1β, at the wound sites while regulating the expression of anti-inflammatory factors, including IL-10 and TGF-β1, throughout the recovery process. The presence of CuS/Qu-CNGs promoted angiogenesis, epithelialization, and collagen synthesis, thereby accelerating wound healing. Our developed CuS/Qu-CNGs nanocomposites have great potential in addressing the challenges associated with delayed wound healing caused by microbial pathogenesis. © 2023 The Royal Society of Chemistry.

Item Type:	Journal Article
Publication:	Nanoscale Horizons
Publisher:	Royal Society of Chemistry
Additional Information:	The copyright for this article belongs to the Royal Society of Chemistry.
Keywords:	Antioxidants; Bacteria; Biofilms; Carbonization; Copper compounds; Flavonoids; Infrared devices; Mammals; Nanoclusters; Nanocomposites; Phenols; Sulfur compounds, Anti-inflammatories; Antioxidative; Carbonization process; Chronic wounds; Inflammatory properties; Minimum inhibitory concentration; Monomerics; Nanogels; Property; Wound healing, Nanogels
Department/Centre:	Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	18 Dec 2023 04:17
Last Modified:	18 Dec 2023 04:17
URI:	https://eprints.iisc.ac.in/id/eprint/83501

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