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Trends in Photopolymerizable Bioinks for 3D Bioprinting of Tumor Models

Gugulothu, SB and Asthana, S and Homer-Vanniasinkam, S and Chatterjee, K (2023) Trends in Photopolymerizable Bioinks for 3D Bioprinting of Tumor Models. In: JACS Au, 3 (8). 2086 -2106.

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Official URL: https://doi.org/10.1021/jacsau.3c00281


Three-dimensional (3D) bioprinting technologies involving photopolymerizable bioinks (PBs) have attracted enormous attention in recent times owing to their ability to recreate complex structures with high resolution, mechanical stability, and favorable printing conditions that are suited for encapsulating cells. 3D bioprinted tissue constructs involving PBs can offer better insights into the tumor microenvironment and offer platforms for drug screening to advance cancer research. These bioinks enable the incorporation of physiologically relevant cell densities, tissue-mimetic stiffness, and vascularized channels and biochemical gradients in the 3D tumor models, unlike conventional two-dimensional (2D) cultures or other 3D scaffold fabrication technologies. In this perspective, we present the emerging techniques of 3D bioprinting using PBs in the context of cancer research, with a specific focus on the efforts to recapitulate the complexity of the tumor microenvironment. We describe printing approaches and various PB formulations compatible with these techniques along with recent attempts to bioprint 3D tumor models for studying migration and metastasis, cell-cell interactions, cell-extracellular matrix interactions, and drug screening relevant to cancer. We discuss the limitations and identify unexplored opportunities in this field for clinical and commercial translation of these emerging technologies. © 2023 The Authors. Published by American Chemical Society.

Item Type: Journal Article
Publication: JACS Au
Publisher: American Chemical Society
Additional Information: The copyright for this article belongs to the Authors.
Department/Centre: Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited: 05 Nov 2023 05:56
Last Modified: 05 Nov 2023 05:56
URI: https://eprints.iisc.ac.in/id/eprint/83078

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