Regenerative bioelectronics: A strategic roadmap for precision medicine

Panda, AK and Basu, B (2023) Regenerative bioelectronics: A strategic roadmap for precision medicine. In: Biomaterials, 301 .

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Abstract

In the past few decades, stem cell-based regenerative engineering has demonstrated its significant potential to repair damaged tissues and to restore their functionalities. Despite such advancement in regenerative engineering, the clinical translation remains a major challenge. In the stance of personalized treatment, the recent progress in bioelectronic medicine likewise evolved as another important research domain of larger significance for human healthcare. Over the last several years, our research group has adopted biomaterials-based regenerative engineering strategies using innovative bioelectronic stimulation protocols based on either electric or magnetic stimuli to direct cellular differentiation on engineered biomaterials with a range of elastic stiffness or functional properties (electroactivity/magnetoactivity). In this article, the role of bioelectronics in stem cell-based regenerative engineering has been critically analyzed to stimulate futuristic research in the treatment of degenerative diseases as well as to address some fundamental questions in stem cell biology. Built on the concepts from two independent biomedical research domains (regenerative engineering and bioelectronic medicine), we propose a converging research theme, �Regenerative Bioelectronics�. Further, a series of recommendations have been put forward to address the current challenges in bridging the gap in stem cell therapy and bioelectronic medicine. Enacting the strategic blueprint of bioelectronic-based regenerative engineering can potentially deliver the unmet clinical needs for treating incurable degenerative diseases. © 2023 Elsevier Ltd

Item Type:	Journal Article
Publication:	Biomaterials
Publisher:	Elsevier Ltd
Additional Information:	The copyright for this article belongs to the Elsevier Ltd.
Keywords:	Cell engineering; Cytology; Diseases, Bioelectronic medicine; Biophysical cue; Cell-based; Clinical translation; Degenerative disease; Recent progress; Research domains; Research groups; Roadmap; Stem-cell, Stem cells
Department/Centre:	Division of Chemical Sciences > Materials Research Centre Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited:	07 Nov 2023 11:12
Last Modified:	07 Nov 2023 11:12
URI:	https://eprints.iisc.ac.in/id/eprint/83027

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