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Combatting intracellular pathogens using bacteriophage delivery

Goswami, A and Sharma, PR and Agarwal, R (2021) Combatting intracellular pathogens using bacteriophage delivery. In: Critical Reviews in Microbiology, 47 (4). pp. 461-478.

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Official URL: https://doi.org/10.1080/1040841X.2021.1902266


Intracellular pathogens reside in specialised compartments within the host cells restricting the access of antibiotics. Insufficient intracellular delivery of antibiotics along with several other resistance mechanisms weaken the efficacy of current therapies. An alternative to antibiotic therapy could be bacteriophage (phage) therapy. Although phage therapy has been in practice for a century against various bacterial infections, the efficacy of phages against intracellular bacteria is still being explored. In this review, we will discuss the advancement and challenges in phage therapy, particularly against intracellular bacterial pathogens. Finally, we will highlight the uptake mechanisms and approaches to overcome the challenges to phage therapy against intracellular bacteria.

Item Type: Journal Article
Publication: Critical Reviews in Microbiology
Publisher: Taylor and Francis Ltd.
Additional Information: The copyright for this article belongs to the Authors.
Keywords: Antibiotic resistance; intracellular phage delivery; particle engineering; phage uptake
Department/Centre: Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 09 Nov 2023 06:14
Last Modified: 09 Nov 2023 06:14
URI: https://eprints.iisc.ac.in/id/eprint/82835

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