Evidence for the Successful Manipulation of a Magnetic Nanorobot Inside the Hard Tumor of a Live Animal

Goswami, S and Ramachandran, RV and Bhat, R and Dasgupta, D and Barman, A and Saini, DK and Ghosh, A (2022) Evidence for the Successful Manipulation of a Magnetic Nanorobot Inside the Hard Tumor of a Live Animal. In: 2022 IEEE International Conference on Emerging Electronics, 11- 14 Dec 2022, Bangalore.

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Abstract

Observation of nano/micron-scale objects inside living tissue is a significant challenge in all nanoparticle drug delivery research. Helical Magnetic Nanorobots[1] (HMNs) also face this problem, where any translation due to a rotating magnetic field is not readily observable. The problem arises due to the scattering nature of living tissue. Here we demonstrate a new technique to determine if HMNs have achieved translation by post-experimental analysis of tissue. We use non-magnetic tracer particles to identify the site of injection. The diffusive spread of HMNs is minimal due to the rigidity of the tissue. By observing the microtome slices of the tissue, we could observe HMNs far from their injection site, which would be possible only due to magnetic field-induced translation. This allows us to calculate the pitch of HMNs inside a living tissue to be about 20-25 nm.

Item Type:	Conference Paper
Publication:	2022 IEEE International Conference on Emerging Electronics, ICEE 2022
Publisher:	Institute of Electrical and Electronics Engineers Inc.
Additional Information:	The copyright for this article belongs to Institute of Electrical and Electronics Engineers Inc.
Keywords:	Biomedical applications; Helical magnetic nanorobots; live animal; rotating magnetic field; Tumor
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering Division of Interdisciplinary Sciences > Centre for Nano Science and Engineering Division of Physical & Mathematical Sciences > Physics
Date Deposited:	27 Jun 2023 07:36
Last Modified:	27 Jun 2023 07:36
URI:	https://eprints.iisc.ac.in/id/eprint/82173

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