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Visible Light-Based 4D-Bioprinted Tissue Scaffold

Gugulothu, SB and Chatterjee, K (2023) Visible Light-Based 4D-Bioprinted Tissue Scaffold. In: ACS Macro Letters, 12 (4). pp. 494-502.

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Official URL: https://doi.org/10.1021/acsmacrolett.3c00036


Emerging four-dimensional (4D) printing strategies offer improved alternatives to conventional three-dimensional (3D)-bioprinted structures for better compliance and simplicity of application for tissue engineering. Little is reported on simple 3D-bioprinted structures prepared by digital light processing (DLP) that can change shape-to-complex constructs (4D bioprinting) in response to cell-friendly stimuli, such as hydration. In the current research work, a bioink consisting of a blend of gelatin methacryloyl (GelMA) and poly(ethylene glycol) dimethacrylate (PEGDM) with a photoinitiator and a photoabsorber was developed and printed by DLP-based 3D bioprinting operated with visible light (405 nm). The 3D-bioprinted constructs combined with differential cross-linking due to photoabsorber-induced light attenuation were leveraged to realize structural anisotropy, which led to rapid shape deformation (as low as ≈30 min) upon hydration. The sheet thickness influenced the degree of curvature, whereas the incorporation of angled strands provided control of the deformation of the 3D-printed structure. The 4D-bioprinted gels supported the viability and proliferation of cells. Overall, this study introduces a cytocompatible bioink formulation for 4D bioprinting to yield shape-morphing, cell-laden hydrogels for tissue engineering.

Item Type: Journal Article
Publication: ACS Macro Letters
Publisher: American Chemical Society
Additional Information: The copyright for this article belongs to American Chemical Society.
Keywords: 3D printing; Cell engineering; Engineering research; Polyethylene glycols; Scaffolds (biology); Tissue, 'current; Bioprinting; Cross linking; Digital light processing; Photoinitiators; Poly(ethylene glycol) dimethacrylate; Simple++; Tissue scaffolds; Tissues engineerings; Visible light, Hydration
Department/Centre: Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited: 25 May 2023 04:21
Last Modified: 25 May 2023 04:21
URI: https://eprints.iisc.ac.in/id/eprint/81519

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