Sarkar, S and Ali, MZ and Choubey, S (2023) Efficacy of information transmission in cellular communication. In: Physical Review Research, 5 (1).
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Abstract
Cell signaling is essential for individual cells to execute various tasks and respond to changes in their environment. It is carried out via diffusing molecules, whose transport is often aided by directional advection. How diffusion and advection together impact the accuracy of information transmission during signaling remains poorly understood. Here, we study this problem using a simplified model of signal transport in the presence and absence of crowding. Mutual information, our measure of accuracy, shows three distinct regimes characterized by power-law decay. Surprisingly, crowding has no measurable effect on information transmission. Our results provide several important insights into the role of transport in cell signaling. © 2023 authors. Published by the American Physical Society. Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.
| Item Type: | Journal Article |
|---|---|
| Publication: | Physical Review Research |
| Publisher: | American Physical Society |
| Additional Information: | The copyright for this article belongs to the Authors. |
| Keywords: | Advection; Signaling, Accuracy of information; Cells signaling; Individual cells; Information transmission; Mutual informations; Power law decay, Cell signaling |
| Department/Centre: | Division of Physical & Mathematical Sciences > Physics |
| Date Deposited: | 21 Apr 2023 10:50 |
| Last Modified: | 21 Apr 2023 10:50 |
| URI: | https://eprints.iisc.ac.in/id/eprint/81383 |
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