Nanoceria-decorated Graphene Nanosheets Enhance Mechanical Properties and Bioactivity of a Degradable Polyurethane for Biomedical Applications

Nilawar, Sagar and Bs, Mohankumar and Chatterjee, Kaushik (2023) Nanoceria-decorated Graphene Nanosheets Enhance Mechanical Properties and Bioactivity of a Degradable Polyurethane for Biomedical Applications. In: Journal of Polymers and the Environment .

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Abstract

Redox-modulating ceria nanoparticles can impart bioactivity to biodegradable polymers for tissue regeneration but are limited by poor dispersion in the polymer matrix. Toward the development of biodegradable multifunctional biomaterials, cerium oxide (ceria)-decorated graphene-based hybrid nanoparticles were used as nanofillers in a polyurethane matrix. The polyurethane was synthesized using olive oil-based polyol to impart degradability to the composite. Hybrid nanoparticles consisting of ceria anchored on graphene sheets were synthesized by the hydrothermal process. X-ray diffraction, transmission electron microscopy, and X-ray photoelectron spectroscopy confirmed the anchoring of ceria nanoparticles on the graphene sheets. Polyurethane composites were prepared by in situ polymerization. Hybrid nanoparticle-infused composites showed uniform dispersion, unlike the agglomerated particles in ceria-infused composites. The hybrid nanocomposite showed improved mechanical properties compared to the ceria nanocomposite. The nanocomposite was non-toxic to pre-osteoblasts. The polyurethane demonstrated enhanced radical-scavenging potential after adding the hybrid nanoparticles in contrast to a neat polymer or graphene oxide-infused composite. The cells exhibited improved osteogenic differentiation on the hybrid composites than on the neat polyurethane or the GO-composite. Thus, the graphene and ceria in the hybrid particles synergistically render multifunctional properties to polyurethanes for potential application in bone tissue regeneration. Graphical Abstract: Figure not available: see fulltext.. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Item Type:	Journal Article
Publication:	Journal of Polymers and the Environment
Publisher:	Springer
Additional Information:	The copyright of this article belongs to Springer.
Keywords:	Ceria; Hybrid nanoparticles; Nanocomposite; Osteogenesis; ROS scavenging
Department/Centre:	Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	10 Mar 2023 05:43
Last Modified:	10 Mar 2023 05:43
URI:	https://eprints.iisc.ac.in/id/eprint/80932

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