Antagonism and Evasion of Cellular Innate Immunity by SARS-CoV-2

Swaraj, S and Malpani, T and Tripathi, S (2022) Antagonism and Evasion of Cellular Innate Immunity by SARS-CoV-2. [Book Chapter]

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Abstract

The replication cycle of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) shares many features with other human Coronaviruses such as SARS-CoV and Middle East respiratory syndrome Coronavirus (MERS-CoV). Recent studies have elucidated the viral strategies of antagonizing the host immune response, including a multitude of mechanisms by which SARS-CoV-2 can dampen the interferon-mediated innate immunity. Furthermore, an imbalance and delay in interferon production, and exaggerated secretion of pro-inflammatory cytokines contribute to the severe immunopathology of Coronavirus disease 2019 (COVID-19). This chapter summarizes our current understanding of the intimate relationship between SARS-CoV-2 and the host innate and adaptive immune responses. The strategies that the virus utilizes to exploit cellular resources and to evade the innate immune system are described. The chapter provides a detailed discussion of interferonmediated innate immunity, interferon evasion and antagonism by SARSCoV- 2 and human Coronaviruses. © 2023 by World Scientific Publishing Co. Pte. Ltd.

Item Type:	Book Chapter
Publication:	Uncovering The Science of Covid-19
Publisher:	World Scientific Publishing Co.
Additional Information:	The copyright of this article belongs to World Scientific Publishing Co.
Keywords:	COVID-19; cytokine storm; innate immunity; interferon induction; interferon signaling; SARS-CoV-2; viral antagonism; viral evasion; virus–host interactions
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology Division of Biological Sciences > Centre for Infectious Disease Research
Date Deposited:	12 Mar 2023 05:12
Last Modified:	14 Mar 2023 07:36
URI:	https://eprints.iisc.ac.in/id/eprint/80915

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