Methacrylated alkali lignin grafted P(Nipam-Co-AAc) copolymeric hydrogels: Tuning the mechanical and stimuli-responsive properties

Parvathy, PA and Ayobami, AV and Raichur, AM and Sahoo, SK (2021) Methacrylated alkali lignin grafted P(Nipam-Co-AAc) copolymeric hydrogels: Tuning the mechanical and stimuli-responsive properties. In: International Journal of Biological Macromolecules, 192 . pp. 180-196.

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Abstract

The current study reports the preparation of lignin grafted temperature and pH responsive hydrogels through copolymerization of N-isopropylacrylamide, acrylic acid and varying amount of lignin methacrylate (LMA = 50, 100, 150 and 200 mg) as crosslinker adopting radical polymerization technique. Functional group and structural characterizations were carried out to confirm hydrogels synthesis and their network structure. The variation in pore size on addition of lignin revealed the tuning of pores as well as swelling capacity of the hydrogels by suitable amount of LMA. All LMA grafted hydrogels showed temperature responsive behavior and pH dependent sensitivity in swelling, with reduced equilibrium swelling capacity values compared to sample without lignin. In alkali medium at room temperature, the maximum swelling capacity with 48% higher retention was noticed, while a significant reduction in swelling was observed at 40 °C in all media. The addition of lignin still preserved the tensile strength up to 100 kPa and compressive load bearing ability up to 30 kPa in freeze dried state with adequate interfacial stress transfer. An increase in lignin concentration showed enhanced storage modulus (~two-fold increase), adequate loss modulus values and improved cell viability, which paves the way for possible biomedical applications.

Item Type:	Journal Article
Publication:	International Journal of Biological Macromolecules
Publisher:	Elsevier B.V.
Additional Information:	The copyright for this article belongs to Elsevier B.V.
Keywords:	alkali; copolymer; hydrogel; lignin; methacrylated alkali lignin; p(NIPAM-co-AAc); unclassified drug; alkali; biomaterial; lignin; methacrylic acid; polymer, Article; biocompatibility; controlled study; mechanical test; pH; stimulus response; temperature; chemical phenomena; chemical structure; chemistry; hydrogel; mechanics; nuclear magnetic resonance spectroscopy; porosity; spectroscopy; thermogravimetry, Alkalies; Biocompatible Materials; Chemical Phenomena; Hydrogels; Hydrogen-Ion Concentration; Lignin; Magnetic Resonance Spectroscopy; Mechanical Phenomena; Methacrylates; Molecular Structure; Polymers; Porosity; Spectrum Analysis; Temperature; Thermogravimetry
Department/Centre:	Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	18 Apr 2023 10:03
Last Modified:	18 Apr 2023 10:03
URI:	https://eprints.iisc.ac.in/id/eprint/80651

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