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Zinc and cerium synergistically enhance the mechanical properties, corrosion resistance, and osteogenic activity of magnesium as resorbable biomaterials

Behera, M and Rajput, M and Acharya, S and Nadammal, N and Suwas, S and Chatterjee, K (2021) Zinc and cerium synergistically enhance the mechanical properties, corrosion resistance, and osteogenic activity of magnesium as resorbable biomaterials. In: Biomedical Materials (Bristol), 16 (4).

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Official URL: https://doi.org/10.1088/1748-605X/ac0453


Magnesium and its alloys have the potential to serve as a revolutionary class of biodegradable materials, specifically in the field of degradable implants for orthopedics. However, the corrosion rate of commercially pure magnesium is high and does not match the rate of regeneration of bone tissues. In this work, magnesium alloys containing zinc and cerium, either alone or in combination, were investigated and compared with commercially-pure magnesium as biomaterials. The microstructure, mechanical properties, corrosion resistance, and response of osteoblasts in vitro were systematically assessed. Results reveal that alloying with Ce results in grain refinement and weakening of texture. The tensile test revealed that the ternary alloy offered the best combination of elastic modulus (41.1 0.5 GPa), tensile strength (234.5 4.5 MPa), and elongation to break (17.1 0.4). The ternary alloy was also the most resistant to corrosion (current of 0.85 0.05 10-4 A cm-2) in simulated body fluid than the other alloys. The response of MC3T3-E1 cells in vitro revealed that the ternary alloy imparts minimal cytotoxicity. Interestingly, the ternary alloy was highly efficient in supporting osteogenic differentiation, as revealed by the expression of alkaline phosphatase and calcium deposition. In summary, the extruded Mg alloy containing both Zn and Ce exhibits a combination of mechanical properties, corrosion resistance, and cell response that is highly attractive for engineering biodegradable orthopedic implants. © 2021 IOP Publishing Ltd.

Item Type: Journal Article
Publication: Biomedical Materials (Bristol)
Publisher: IOP Publishing Ltd
Additional Information: The copyright for this article belongs to IOP Publishing Ltd.
Keywords: Biomechanics; Body fluids; Bone; Cell engineering; Cerium; Corrosion rate; Corrosion resistance; Corrosion resistant alloys; Grain refinement; Magnesium printing plates; Metal testing; Phosphatases; Tensile strength; Tensile testing; Ternary alloys; Textures; Zinc, ALkaline phosphatase; Biodegra-dable materials; Elongation to break; Magnesium and its alloys; Orthopedic implant; Osteogenic activity; Osteogenic differentiation; Simulated body fluids, Magnesium alloys, alkaline phosphatase; alloy; calcium; cerium; magnesium; mercurous chloride; zinc; alloy; biomaterial; cerium; magnesium; zinc, animal cell; Article; biocompatibility; body fluid; bone development; colorimetry; controlled study; corrosion; cytotoxicity; degradation; field emission scanning electron microscopy; fluorescence microscopy; freeze thawing; human; human cell; in vitro study; MC3T3-E1 cell line; mechanics; microscopy; mouse; nonhuman; osteoblast; oxidation; particle size; platinum electrode; protein expression; tensile strength; wettability; X ray diffraction; Young modulus; animal; biodegradable implant; bone development; cell line; cell survival; chemistry; corrosion; drug effect; materials testing; metabolism, Absorbable Implants; Alloys; Animals; Biocompatible Materials; Cell Line; Cell Survival; Cerium; Corrosion; Elastic Modulus; Magnesium; Materials Testing; Mice; Osteoblasts; Osteogenesis; Zinc
Department/Centre: Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited: 21 Feb 2023 03:12
Last Modified: 21 Feb 2023 03:12
URI: https://eprints.iisc.ac.in/id/eprint/80510

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