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Bioinspired nanostructured bactericidal surfaces

Patil, D and Overland, M and Stoller, M and Chatterjee, K (2021) Bioinspired nanostructured bactericidal surfaces. In: Current Opinion in Chemical Engineering, 34 .

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Official URL: https://doi.org/10.1016/j.coche.2021.100741


The rise of antimicrobial resistance as a pressing global healthcare challenge underscores the need to identify novel strategies to tackle pathogenic bacteria. Many naturally occurring nanostructures exhibit an innate ability to deactivate bacterial cells by physical contact. However, several aspects of the underlying mechanisms are poorly understood due to the complex interactions of bacterial cells with nanostructures, which are difficult to simulate using theoretical models. This review describes the experimental reports of the state-of-the-art in designing bioinspired mechano-bactericidal surfaces and theoretical models to elucidate underlying phenomena at the cell–material interface. The different processes used to make nanostructured surfaces and their effects on bactericidal activity are summarized. Recent findings disputing the current understanding are critically discussed. Lastly, the challenges and opportunities in fabricating nanostructures on devices and implants for clinical use are presented.

Item Type: Journal Article
Publication: Current Opinion in Chemical Engineering
Publisher: Elsevier Ltd
Additional Information: The copyright for this article belongs to Elsevier Ltd.
Keywords: Bacteria; Interface states, Antimicrobial resistances; Bacterial cells; Bactericidal surface; Nano-structured; Naturally occurring; Novel strategies; Pathogenic bacterium; Physical contacts; Pressung; Theoretical modeling, Nanostructures
Department/Centre: Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited: 21 Feb 2023 03:06
Last Modified: 21 Feb 2023 03:06
URI: https://eprints.iisc.ac.in/id/eprint/80497

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