Biomaterials-based bioengineering strategies for bioelectronic medicine

Panda, AK and Basu, B (2021) Biomaterials-based bioengineering strategies for bioelectronic medicine. In: Materials Science and Engineering R: Reports, 146 .

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Abstract

The field of bioelectronic medicine has witnessed significant developments over the last two decades. However, the ability to precisely control the cell functionalities remains a major constraint in translating research outcomes to implantable bioelectronic devices. Various biophysical cues such as matrix stiffness, mechanical forces, substrate topography, and external electrical stimulation are being investigated to modulate cellular functions. In this perspective, the bioengineering approach of integrating electronic systems with biomaterial scaffolds can be adapted to monitor the cellular physiology within the engineered tissue. In this critical review, we have comprehensively analysed the applications of electroactive biomaterials to deliver bioelectrical cues for regulating cell fate processes. Along with the fundamental physical phenomenon at the tissue-electrode interface, the advancements in nanoelectronic devices in pre-clinical and clinical studies have been summarized. While the stiff and rigid electronics bring-forth the challenges in the biointegration and electrical performance; soft and flexible electronics, in contrast, have emerged as next-generation bioelectronic devices with a more stable and compatible biointerface. We have outlined various state-of-the-art approaches to develop bioresorbable electronics that can be eliminated from the body after a stipulated time, without further intervention. In addition, clinically-led bioelectronics medicine to regulate the electrical signaling at the neural interface has been highlighted. In summary, this review envisions the strategies of biomaterials-based biophysical stimulations to be adopted in bioelectronics-based advanced tissue engineering approaches that may eventually allow us to potentially realize the development of bioartificial organs. © 2021 Elsevier B.V.

Item Type:	Journal Article
Publication:	Materials Science and Engineering R: Reports
Publisher:	Elsevier Ltd
Additional Information:	The copyright for this article belongs to Elsevier Ltd.
Keywords:	Artificial organs; Flexible electronics; Stiffness matrix; Tissue; Topography, Bioartificial organs; Biomaterial scaffolds; Biophysical stimulation; Electrical performance; External electrical stimulations; Nanoelectronic devices; State-of-the-art approach; Substrate topography, Scaffolds (biology)
Department/Centre:	Division of Chemical Sciences > Materials Research Centre Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited:	22 Feb 2023 03:56
Last Modified:	22 Feb 2023 03:56
URI:	https://eprints.iisc.ac.in/id/eprint/80466

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