Unique sphingolipid signature identifies luminal and triple-negative breast cancer subtypes

Kar, A and Medatwal, N and Rajput, K and Mandal, S and Pani, T and Khan, A and Sharma, P and Oberoi, AS and Vishwakarma, G and Deo, SVS and Jolly, MK and Bajaj, A and Dasgupta, U (2023) Unique sphingolipid signature identifies luminal and triple-negative breast cancer subtypes. In: International Journal of Cancer .

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Abstract

Breast cancer (luminal and triple-negative breast cancer TNBC) is the most common cancer among women in India and worldwide. Altered sphingolipid levels have emerged as a common phenomenon during cancer progression. However, these alterations are yet to be translated into robust diagnostic and prognostic markers for cancer. Here, we present the quantified sphingolipids of tumor and adjacent-normal tissues from patients of luminal (n = 70) and TNBC (n = 42) subtype from an Indian cohort using targeted liquid chromatography mass spectrometry. We recorded unique sphingolipid profiles that distinguished luminal and TNBC tumors in comparison to adjacent normal tissue by six-sphingolipid signatures. Moreover, systematic comparison of the profiles of luminal and TNBC tumors provided a unique five-sphingolipid signature distinguishing the two subtypes. We further identified key sphingolipids that can stratify grade II and grade III tumors of luminal and TNBC subtype as well as their lymphovascular invasion status. Therefore, we provide the right evidence to develop these candidate sphingolipids as widely acceptable marker/s capable of diagnosing luminal vs TNBC subtype of breast cancer, and predicting the disease severity by identifying the tumor grade. © 2023 UICC.

Item Type:	Journal Article
Publication:	International Journal of Cancer
Publisher:	John Wiley and Sons Inc
Additional Information:	The copyright for this article belongs to John Wiley and Sons Inc.
Keywords:	biomarkers; breast cancer; ceramides; glucosylceramides; sphingolipids; sphingosine
Department/Centre:	Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited:	16 Feb 2023 05:18
Last Modified:	16 Feb 2023 05:18
URI:	https://eprints.iisc.ac.in/id/eprint/80307

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