Spatiotemporal Patterning Enabled by Gene Regulatory Networks

Roy, U and Singh, D and Vincent, N and Haritas, CK and Jolly, MK (2023) Spatiotemporal Patterning Enabled by Gene Regulatory Networks. In: ACS Omega .

PDF ACS_ome_2022.pdf - Published Version Restricted to Registered users only Download (12MB)

Abstract

Spatiotemporal pattern formation plays a key role in various biological phenomena including embryogenesis and neural network formation. Though the reaction-diffusion systems enabling pattern formation have been studied phenomenologically, the biomolecular mechanisms behind these processes have not been modeled in detail. Here, we study the emergence of spatiotemporal patterns due to simple, synthetic and commonly observed two- and three-node gene regulatory network motifs coupled with their molecular diffusion in one- and two-dimensional space. We investigate the patterns formed due to the coupling of inherent multistable and oscillatory behavior of the toggle switch, toggle switch with double self-activation, toggle triad, and repressilator with the effect of spatial diffusion of these molecules. We probe multiple parameter regimes corresponding to different regions of stability (monostable, multistable, oscillatory) and assess the impact of varying diffusion coefficients. This analysis offers valuable insights into the design principles of pattern formation facilitated by these network motifs, and it suggests the mechanistic underpinnings of biological pattern formation. © 2023 The Authors. Published by American Chemical Society.

Item Type:	Journal Article
Publication:	ACS Omega
Publisher:	American Chemical Society
Additional Information:	The copyright for this article belongs to the Authors.
Department/Centre:	Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited:	10 Feb 2023 09:09
Last Modified:	10 Feb 2023 09:09
URI:	https://eprints.iisc.ac.in/id/eprint/80164

Actions (login required)

View Item