Phenotypic Switching: Implications in Biology and Medicine

Levine, H and Jolly, MK and Kulkarni, P and Nanjundiah, V (2020) Phenotypic Switching: Implications in Biology and Medicine. [Book Chapter]

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Abstract

Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance, specific areas of human development and disease relevance, phenotypic plasticity in melanoma, prostate cancer, breast cancer, non-genetic heterogeneity in cancer, hepatitis C, and more. This book is essential for active researchers, basic and translational scientists, clinicians, postgraduates and students in genetics, human genomics, pathology, bioinformatics, developmental biology, evolutionary biology and adaptive opportunities in yeast. © 2020 Elsevier Inc.

Item Type:	Book Chapter
Publication:	Phenotypic Switching: Implications in Biology and Medicine
Publisher:	Elsevier
Additional Information:	The copyright for this article belongs to Elsevier.
Department/Centre:	Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited:	07 Feb 2023 10:53
Last Modified:	07 Feb 2023 10:53
URI:	https://eprints.iisc.ac.in/id/eprint/80017

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