Bistability in virus-host interaction networks underlies the success of hepatitis C treatments

Padmanabhan, P and Raja, R and Dixit, NM (2020) Bistability in virus-host interaction networks underlies the success of hepatitis C treatments. [Book Chapter]

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Abstract

The treatment of hepatitis C virus (HCV) infection is undergoing a paradigm shift with current therapies curing nearly all the patients treated. Significant efforts are now focused on identifying optimal drug combinations to minimize treatment durations, costs, and side effects. Mathematical models of HCV kinetics have provided critical insights into the within-host dynamics of HCV infection and guided treatments. Recent multiscale models have integrated underlying molecular, cellular and population level phenomena and identified emergent, systems-level properties of the virus-host interaction networks that define HCV infection and treatment outcomes, thus presenting quantitative frameworks for rational treatment optimization. In this chapter, we review the advances in our conceptual understanding of HCV pathogenesis and treatment response due to the multiscale models and the new avenues they present for optimizing HCV therapies. © 2020 Elsevier Inc.

Item Type:	Book Chapter
Publication:	Phenotypic Switching: Implications in Biology and Medicine
Publisher:	Elsevier
Additional Information:	The copyright for this article belongs to Elsevier.
Keywords:	Bistability; Direct-acting antivirals; Hepatitis C virus infection; Interferon; Mathematical models; Multiscale models; Viral kinetics
Department/Centre:	Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering Division of Mechanical Sciences > Chemical Engineering
Date Deposited:	07 Feb 2023 04:06
Last Modified:	07 Feb 2023 04:06
URI:	https://eprints.iisc.ac.in/id/eprint/79966

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